7c44

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(New page: '''Unreleased structure''' The entry 7c44 is ON HOLD Authors: Cheng, X.Y., Zhang, B.L., Kuang, Z.K., Yang, J., Li, Z.C., Yu, J.P., Zhao, Z.T., Cao, C.Z., Su, Z.D. Description: Crystal ...)
Current revision (15:55, 29 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7c44 is ON HOLD
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==Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a==
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<StructureSection load='7c44' size='340' side='right'caption='[[7c44]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7c44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C44 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c44 OCA], [https://pdbe.org/7c44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c44 RCSB], [https://www.ebi.ac.uk/pdbsum/7c44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c44 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
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Authors: Cheng, X.Y., Zhang, B.L., Kuang, Z.K., Yang, J., Li, Z.C., Yu, J.P., Zhao, Z.T., Cao, C.Z., Su, Z.D.
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==See Also==
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*[[MDM4|MDM4]]
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Description: Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Su, Z.D]]
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__TOC__
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[[Category: Yang, J]]
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</StructureSection>
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[[Category: Cao, C.Z]]
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[[Category: Homo sapiens]]
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[[Category: Yu, J.P]]
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[[Category: Large Structures]]
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[[Category: Li, Z.C]]
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[[Category: Cao CZ]]
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[[Category: Zhao, Z.T]]
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[[Category: Cheng XY]]
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[[Category: Kuang, Z.K]]
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[[Category: Kuang ZK]]
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[[Category: Zhang, B.L]]
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[[Category: Li ZC]]
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[[Category: Cheng, X.Y]]
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[[Category: Su ZD]]
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[[Category: Yang J]]
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[[Category: Yu JP]]
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[[Category: Zhang BL]]
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[[Category: Zhao ZT]]

Current revision

Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a

PDB ID 7c44

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OCA

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