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5h10
From Proteopedia
(Difference between revisions)
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==TRAF1-TANk complex== | ==TRAF1-TANk complex== | ||
| - | <StructureSection load='5h10' size='340' side='right'caption='[[5h10]]' scene=''> | + | <StructureSection load='5h10' size='340' side='right'caption='[[5h10]], [[Resolution|resolution]] 3.21Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H10 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5h10]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Peptide_display_vector_fth1 Peptide display vector fth1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H10 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.205Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h10 OCA], [https://pdbe.org/5h10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h10 RCSB], [https://www.ebi.ac.uk/pdbsum/5h10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h10 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRAF1_HUMAN TRAF1_HUMAN] Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.<ref>PMID:10692572</ref> <ref>PMID:16323247</ref> <ref>PMID:18429822</ref> <ref>PMID:19698991</ref> <ref>PMID:19287455</ref> <ref>PMID:20385093</ref> | ||
==See Also== | ==See Also== | ||
*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]] | *[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Peptide display vector fth1]] | ||
[[Category: Kim CM]] | [[Category: Kim CM]] | ||
[[Category: Park HH]] | [[Category: Park HH]] | ||
Current revision
TRAF1-TANk complex
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