5h9d

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<StructureSection load='5h9d' size='340' side='right'caption='[[5h9d]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
<StructureSection load='5h9d' size='340' side='right'caption='[[5h9d]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5h9d]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5H9D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5h9d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H9D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5h9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9d OCA], [http://pdbe.org/5h9d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9d RCSB], [http://www.ebi.ac.uk/pdbsum/5h9d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9d ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9d OCA], [https://pdbe.org/5h9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h9d RCSB], [https://www.ebi.ac.uk/pdbsum/5h9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9d ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q2FYG6_STAA8 Q2FYG6_STAA8]
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We report the first structure of heptaprenyl diphosphate synthase from Staphylococcus aureus (SaHepPPS), together with an investigation of its mechanism of action and inhibition. The protein is involved in the formation of menaquinone, a key electron transporter in many bacteria, including pathogens. SaHepPPS consists of a "catalytic " subunit (SaHepPPS-2) having two "DDXXD" motifs and a "regulatory" subunit (SaHepPPS-1) that lacks these motifs. High concentrations of the substrates, isopentenyl diphosphate and farnesyl diphosphate, inhibit the enzyme, which is also potently inhibited by bisphosphonates. The most active inhibitors (Ki approximately 200 nm) were N-alkyl analogues of zoledronate containing approximately C6 alkyl side chains. They were modestly active against S. aureus cell growth, and growth inhibition was partially "rescued" by the addition of menaquinone-7. Because SaHepPPS is essential for S. aureus cell growth, its structure is of interest in the context of the development of menaquinone biosynthesis inhibitors as potential antibiotic leads.
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Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.,Desai J, Liu YL, Wei H, Liu W, Ko TP, Guo RT, Oldfield E ChemMedChem. 2016 Sep 6;11(17):1915-23. doi: 10.1002/cmdc.201600311. Epub 2016, Jul 26. PMID:27457559<ref>PMID:27457559</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5h9d" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, C C]]
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[[Category: Staphylococcus aureus]]
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[[Category: Guo, R T]]
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[[Category: Chen CC]]
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[[Category: Ko, T P]]
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[[Category: Guo RT]]
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[[Category: Liu, W D]]
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[[Category: Ko TP]]
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[[Category: Wei, H L]]
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[[Category: Liu WD]]
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[[Category: Zheng, Y Y]]
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[[Category: Wei HL]]
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[[Category: Acidocalcisomal pyrophosphatase]]
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[[Category: Zheng YY]]
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[[Category: Metal-binding]]
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[[Category: Substrate binding]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Heptaprenyl Diphosphate Synthase from Staphylococcus aureus

PDB ID 5h9d

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