This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5hem

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:33, 9 August 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5hem' size='340' side='right'caption='[[5hem]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='5hem' size='340' side='right'caption='[[5hem]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5hem]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HEM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5hem]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HEM FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD2, KIAA9001, RING3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hem OCA], [http://pdbe.org/5hem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hem RCSB], [http://www.ebi.ac.uk/pdbsum/5hem PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hem ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hem OCA], [https://pdbe.org/5hem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hem RCSB], [https://www.ebi.ac.uk/pdbsum/5hem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hem ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
+
[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
==See Also==
==See Also==
Line 17: Line 17:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C]]
+
[[Category: Bountra C]]
-
[[Category: Chiaraluce, R]]
+
[[Category: Chiaraluce R]]
-
[[Category: Consalvi, V]]
+
[[Category: Consalvi V]]
-
[[Category: Delft, F von]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S]]
+
[[Category: Lori C]]
-
[[Category: Lori, C]]
+
[[Category: Newman JA]]
-
[[Category: Newman, J A]]
+
[[Category: Pasquo A]]
-
[[Category: Pasquo, A]]
+
[[Category: Tallant C]]
-
[[Category: Tallant, C]]
+
[[Category: Von Delft F]]
-
[[Category: Post translational modifications recognition]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+

Current revision

Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2

PDB ID 5hem

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5hem"
Personal tools