6z1w

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'''Unreleased structure'''
 
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The entry 6z1w is ON HOLD until Paper Publication
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==Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C==
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<StructureSection load='6z1w' size='340' side='right'caption='[[6z1w]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
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Authors: Rozeboom, H.J., Janssen, D.B.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6z1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z1W FirstGlance]. <br>
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Description: Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OXN:OXTOXYNOL-10'>OXN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Janssen, D.B]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1w OCA], [https://pdbe.org/6z1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z1w RCSB], [https://www.ebi.ac.uk/pdbsum/6z1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1w ProSAT]</span></td></tr>
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[[Category: Rozeboom, H.J]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN] Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:[https://omim.org/entry/261515 261515]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.<ref>PMID:9482850</ref> <ref>PMID:10400999</ref> <ref>PMID:11743515</ref> Defects in HSD17B4 are the cause of Perrault syndrome (PRLTS1) [MIM:[https://omim.org/entry/233400 233400]. A sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement.<ref>PMID:20673864</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN] Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.<ref>PMID:9089413</ref> <ref>PMID:8902629</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Janssen DB]]
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[[Category: Rozeboom HJ]]

Current revision

Crystal structure of human steroid carrier protein SL (SCP-2L) mutant A100C

PDB ID 6z1w

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