1bdw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:00, 2 August 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1bdw.gif|left|200px]]
 
-
<!--
+
==GRAMICIDIN D FROM BACILLUS BREVIS (ACTIVE FORM)==
-
The line below this paragraph, containing "STRUCTURE_1bdw", creates the "Structure Box" on the page.
+
<StructureSection load='1bdw' size='340' side='right'caption='[[1bdw]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1bdw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BDW FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=FVA:N-FORMYL-L-VALINE'>FVA</scene>, <scene name='pdbligand=PRD_000150:GRAMICIDIN+A'>PRD_000150</scene></td></tr>
-
{{STRUCTURE_1bdw| PDB=1bdw | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bdw OCA], [https://pdbe.org/1bdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bdw RCSB], [https://www.ebi.ac.uk/pdbsum/1bdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bdw ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The linear pentadecapeptide antibiotic, gramicidin D, is a naturally occurring product of Bacillus brevis known to form ion channels in synthetic and natural membranes. The x-ray crystal structures of the right-handed double-stranded double-helical dimers (DSDH) reported here agree with 15N-NMR and CD data on the functional gramicidin D channel in lipid bilayers. These structures demonstrate single-file ion transfer through the channels. The results also indicate that previous crystal structure reports of a left-handed double-stranded double-helical dimer in complex with Cs+ and K+ salts may be in error and that our evidence points to the DSDH as the major conformer responsible for ion transport in membranes.
-
'''GRAMICIDIN D FROM BACILLUS BREVIS (ACTIVE FORM)'''
+
The conducting form of gramicidin A is a right-handed double-stranded double helix.,Burkhart BM, Li N, Langs DA, Pangborn WA, Duax WL Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12950-5. PMID:9789021<ref>PMID:9789021</ref>
-
 
+
-
 
+
-
==Overview==
+
-
The linear pentadecapeptide antibiotic, gramicidin D, is a naturally occurring product of Bacillus brevis known to form ion channels in synthetic and natural membranes. The x-ray crystal structures of the right-handed double-stranded double-helical dimers (DSDH) reported here agree with 15N-NMR and CD data on the functional gramicidin D channel in lipid bilayers. These structures demonstrate single-file ion transfer through the channels. The results also indicate that previous crystal structure reports of a left-handed double-stranded double-helical dimer in complex with Cs+ and K+ salts may be in error and that our evidence points to the DSDH as the major conformer responsible for ion transport in membranes.
+
-
==About this Structure==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDW OCA].
+
</div>
 +
<div class="pdbe-citations 1bdw" style="background-color:#fffaf0;"></div>
-
==Reference==
+
==See Also==
-
The conducting form of gramicidin A is a right-handed double-stranded double helix., Burkhart BM, Li N, Langs DA, Pangborn WA, Duax WL, Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12950-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9789021 9789021]
+
*[[Gramicidin|Gramicidin]]
-
[[Category: Burkhart, B M.]]
+
== References ==
-
[[Category: Duax, W L.]]
+
<references/>
-
[[Category: Pangborn, W A.]]
+
__TOC__
-
[[Category: Peptide antibiotic]]
+
</StructureSection>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:23:18 2008''
+
[[Category: Brevibacillus brevis]]
 +
[[Category: Large Structures]]
 +
[[Category: Burkhart BM]]
 +
[[Category: Duax WL]]
 +
[[Category: Pangborn WA]]

Current revision

GRAMICIDIN D FROM BACILLUS BREVIS (ACTIVE FORM)

PDB ID 1bdw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bdw"
Personal tools