6z36

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(New page: ==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118== <StructureSection load='6z36' size='340' side='right'caption='6z36' scene=''> == Structural highl...)
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==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118==
==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118==
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<StructureSection load='6z36' size='340' side='right'caption='[[6z36]]' scene=''>
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<StructureSection load='6z36' size='340' side='right'caption='[[6z36]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z36 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z36 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6z36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z36 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z36 OCA], [http://pdbe.org/6z36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z36 RCSB], [http://www.ebi.ac.uk/pdbsum/6z36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z36 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=Q5Z:4-methyl-3-(4-piperidin-4-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine'>Q5Z</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z36 OCA], [https://pdbe.org/6z36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z36 RCSB], [https://www.ebi.ac.uk/pdbsum/6z36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z36 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[https://omim.org/entry/135100 135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Adamson RJ]]
[[Category: Adamson RJ]]

Current revision

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118

PDB ID 6z36

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