6s3d

<table><tr><td colspan='2'>[[6s3d]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S3D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S3D FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s3d OCA], [http://pdbe.org/6s3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s3d RCSB], [http://www.ebi.ac.uk/pdbsum/6s3d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s3d ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remains a cornerstone for next-generation vaccines. Here, we present a protein design algorithm called TopoBuilder, with which we engineered epitope-focused immunogens displaying complex structural motifs. In both mice and nonhuman primates, cocktails of three de novo-designed immunogens induced robust neutralizing responses against the respiratory syncytial virus. Furthermore, the immunogens refocused preexisting antibody responses toward defined neutralization epitopes. Overall, our design approach opens the possibility of targeting specific epitopes for the development of vaccines and therapeutic antibodies and, more generally, will be applicable to the design of de novo proteins displaying complex functional motifs.

 

== References ==

[[Category: Human]]

[[Category: Cramer, J T]]

[[Category: Krey, T]]

[[Category: Hrsv]]