5i3t

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<StructureSection load='5i3t' size='340' side='right'caption='[[5i3t]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='5i3t' size='340' side='right'caption='[[5i3t]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i3t]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_defragrans Alcaligenes defragrans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5I3T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i3t]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Castellaniella_defragrans Castellaniella defragrans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I3T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU2:1,3-BUTANEDIOL'>BU2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ldi ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=75697 Alcaligenes defragrans])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU2:1,3-BUTANEDIOL'>BU2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5i3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3t OCA], [http://pdbe.org/5i3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3t RCSB], [http://www.ebi.ac.uk/pdbsum/5i3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3t ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3t OCA], [https://pdbe.org/5i3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i3t RCSB], [https://www.ebi.ac.uk/pdbsum/5i3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LDI_CASDE LDI_CASDE]] Anaerobically catalyzes the stereospecific hydration of beta-myrcene to (3S)-linalool and the isomerization of (3S)-linalool to geraniol. Is thus involved in the initial steps of the anaerobic degradation of the monoterpene beta-myrcene. Also catalyzes the reverse reactions, i.e. the isomerization of geraniol to linalool and the dehydration of linalool to myrcene. In this direction, the formation of myrcene from geraniol may be seen as a detoxification process for the monoterpene alcohol. Neither the monoterpenes alpha- and beta-ocimene nor the monoterpenoids citronellol and nerol can be used as substrates.<ref>PMID:20663876</ref>
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[https://www.uniprot.org/uniprot/LDI_CASD6 LDI_CASD6] Anaerobically catalyzes the stereospecific hydration of beta-myrcene to (3S)-linalool and the isomerization of (3S)-linalool to geraniol (PubMed:20663876, PubMed:28068311, Ref.8). Is thus involved in the initial steps of the anaerobic degradation of the monoterpene beta-myrcene (PubMed:20663876). Also catalyzes the reverse reactions, i.e. the isomerization of geraniol to linalool and the dehydration of linalool to myrcene (PubMed:20663876, PubMed:28068311, Ref.8). In this direction, the formation of myrcene from geraniol may be seen as a detoxification process for the monoterpene alcohol (PubMed:20663876). Shows a relatively broad substrate specificity and can use various geraniol and linalool derivatives (PubMed:28068311). Substrates required a specific alpha-methylallyl alcohol signature motif (PubMed:28068311). Neither the monoterpenes alpha- and beta-ocimene nor the monoterpenoids citronellol and nerol can be used as substrates (PubMed:20663876).<ref>PMID:20663876</ref> <ref>PMID:28068311</ref> [REFERENCE:8]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alcaligenes defragrans]]
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[[Category: Castellaniella defragrans]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Carlock, M]]
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[[Category: Carlock M]]
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[[Category: Koch, D J]]
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[[Category: Koch DJ]]
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[[Category: LaMattina, J W]]
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[[Category: LaMattina JW]]
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[[Category: Lanzilotta, W N]]
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[[Category: Lanzilotta WN]]
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[[Category: Dehydratase]]
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[[Category: Isomerase]]
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[[Category: Linalool]]
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[[Category: Lyase]]
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Current revision

Native Structure of the Linalool Dehydratase-Isomerase from Castellaniella defragrans

PDB ID 5i3t

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