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6yjj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of CYRI-B (FAM49B) from Rhincodon typus (selenomethionine derivative)== | |
| + | <StructureSection load='6yjj' size='340' side='right'caption='[[6yjj]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6yjj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhincodon_typus Rhincodon typus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YJJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YJJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fam49b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=259920 Rhincodon typus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yjj OCA], [http://pdbe.org/6yjj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yjj RCSB], [http://www.ebi.ac.uk/pdbsum/6yjj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yjj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In eukaryotes, numerous fundamental processes are controlled by the WAVE regulatory complex (WRC) that regulates cellular actin polymerization, crucial for cell motility, cell-cell adhesion and epithelial differentiation. Actin assembly is triggered by interaction of the small GTPase Rac1 with CYFIP1, a key component of the WRC. Previously known as FAM49B, CYRI-B is a protein that is highly conserved across the Eukaryota and has recently been revealed to be a key regulator of Rac1 activity. Mutation of CYRI-B or alteration of its expression therefore leads to altered actin nucleation dynamics, with impacts on lamellipodia formation, cell migration and infection by intracellular pathogens. In addition, knockdown of CYRI-B expression in cancer cell lines results in accelerated cell proliferation and invasiveness. Here, the structure of Rhincodon typus (whale shark) CYRI-B is presented, which is the first to be reported of any CYRI family member. Solved by X-ray crystallography, the structure reveals that CYRI-B comprises three distinct alpha-helical subdomains and is highly structurally related to a conserved domain present in CYFIP proteins. The work presented here establishes a template towards a better understanding of CYRI-B biological function. | ||
| - | + | Structure of CYRI-B (FAM49B), a key regulator of cellular actin assembly.,Kaplan E, Stone R, Hume PJ, Greene NP, Koronakis V Acta Crystallogr D Struct Biol. 2020 Oct 1;76(Pt 10):1015-1024. doi:, 10.1107/S2059798320010906. Epub 2020 Sep 23. PMID:33021503<ref>PMID:33021503</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6yjj" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rhincodon typus]] | ||
| + | [[Category: Kaplan, E]] | ||
| + | [[Category: Actin assembly]] | ||
| + | [[Category: Cell motility regulator]] | ||
| + | [[Category: Cyri-b]] | ||
| + | [[Category: Cytosolic protein]] | ||
| + | [[Category: Fam49b]] | ||
| + | [[Category: Rac binding protein]] | ||
Current revision
Structure of CYRI-B (FAM49B) from Rhincodon typus (selenomethionine derivative)
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