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6z4a

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m (Protected "6z4a" [edit=sysop:move=sysop])
Current revision (07:50, 7 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6z4a is ON HOLD until Paper Publication
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==Structure of the human SAS-6 N-terminal domain, F131E mutant==
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<StructureSection load='6z4a' size='340' side='right'caption='[[6z4a]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
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Authors: Busch, J.M.C., Vakonakis, I.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6z4a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z4A FirstGlance]. <br>
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Description: Structure of the human SAS-6 N-terminal domain, F131E mutant
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Busch, J.M.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z4a OCA], [https://pdbe.org/6z4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z4a RCSB], [https://www.ebi.ac.uk/pdbsum/6z4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z4a ProSAT]</span></td></tr>
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[[Category: Vakonakis, I]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SAS6_HUMAN SAS6_HUMAN] Autosomal recessive primary microcephaly. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SAS6_HUMAN SAS6_HUMAN] Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124).<ref>PMID:15665853</ref> <ref>PMID:16244668</ref> <ref>PMID:17681131</ref> <ref>PMID:22020124</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Busch JMC]]
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[[Category: Vakonakis I]]

Current revision

Structure of the human SAS-6 N-terminal domain, F131E mutant

PDB ID 6z4a

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