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7brc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the TMK3 LRR domain== | |
| + | <StructureSection load='7brc' size='340' side='right'caption='[[7brc]], [[Resolution|resolution]] 2.06Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7brc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BRC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7brc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7brc OCA], [https://pdbe.org/7brc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7brc RCSB], [https://www.ebi.ac.uk/pdbsum/7brc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7brc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TMK3_ARATH TMK3_ARATH] Involved in auxin signal transduction and cell expansion and proliferation regulation (PubMed:23613767).<ref>PMID:23613767</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Transmembrane kinases (TMKs) are members of the plant receptor-like kinase (RLK) family. TMKs are characterized by an extracellular leucine-rich-repeat (LRR) domain, a single transmembrane region and a cytoplasmic kinase domain. TMKs have been shown to act as critical modulators of cell expansion and cell proliferation. Here, the crystal structure of the extracellular domain of TMK3 (TMK3-ECD) was determined to a resolution of 2.06 A, with an Rwork of 17.69% and an Rfree of 20.58%. Similar to the extracellular domain of TMK1, the TMK3-ECD structure contains two solenoids with 13 LRRs and a non-LRR region (316-364) between the tenth and 11th LRRs. A comparison of TMK3-ECD with other LRR-RLKs that contain a non-LRR region indicates that the non-LRR region plays a critical role in structural integrity and may contribute to ligand interactions. The non-LRR region of TMK3-ECD is characterized by two disulfide bonds that may have critical biological implications. | ||
| - | + | Crystal structure of the extracellular domain of the receptor-like kinase TMK3 from Arabidopsis thaliana.,Chen H, Kong Y, Chen J, Li L, Li X, Yu F, Ming Z Acta Crystallogr F Struct Biol Commun. 2020 Aug 1;76(Pt 8):384-390. doi:, 10.1107/S2053230X20010122. Epub 2020 Jul 29. PMID:32744250<ref>PMID:32744250</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7brc" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arabidopsis thaliana]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen H]] | ||
| + | [[Category: Chen J]] | ||
| + | [[Category: Kong YQ]] | ||
| + | [[Category: Li L]] | ||
| + | [[Category: Li XS]] | ||
| + | [[Category: Ming ZH]] | ||
| + | [[Category: Yu F]] | ||
Current revision
Crystal structure of the TMK3 LRR domain
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Categories: Arabidopsis thaliana | Large Structures | Chen H | Chen J | Kong YQ | Li L | Li XS | Ming ZH | Yu F
