2pgh

<table><tr><td colspan='2'>[[2pgh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1pgh 1pgh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PGH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2PGH FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2pgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pgh OCA], [http://pdbe.org/2pgh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pgh RCSB], [http://www.ebi.ac.uk/pdbsum/2pgh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pgh ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/HBA_PIG HBA_PIG]] Involved in oxygen transport from the lung to the various peripheral tissues. [[http://www.uniprot.org/uniprot/HBB_PIG HBB_PIG]] Involved in oxygen transport from the lung to the various peripheral tissues.

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== Publication Abstract from PubMed ==

Considerable attention is currently focused on hemoglobins from lower mammals, such as the pig, for potential use in cell-free blood substitute preparations safe for use in humans. As the first step in the elucidation of structure-function relationships in porcine hemoglobin, we have determined the three-dimensional structure of aquomet porcine hemoglobin at 2.8 A resolution. Overall, the porcine hemoglobin tetramer is structurally similar to that of human oxyhemoglobin, and the r.m.s. deviation of all backbone atoms (minus five residues at the amino and carboxyl termini of each subunit) is 0.8 A. This similarity is not unexpected given that human and porcine hemoglobins exhibit 85% sequence identity. However, regions of subtle structural differences are implicated in subtle functional differences between the two proteins, such as the 20 to 25% inhibition of the alkaline Bohr effect and the accompanying reduction in oxygen-linked chloride binding observed for porcine hemoglobin. The structural similarity of these two mammalian hemoglobins also rationalizes the novel hybridization behavior of pig and human subunits in transgenic pigs expressing both porcine and human hemoglobins in porcine erythrocytes.

Structure determination of aquomet porcine hemoglobin at 2.8 A resolution.,Katz DS, White SP, Huang W, Kumar R, Christianson DW J Mol Biol. 1994 Dec 16;244(5):541-53. PMID:7990139<ref>PMID:7990139</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Pig]]

[[Category: Christianson, D W]]

[[Category: Huang, W]]

[[Category: Katz, D S]]

[[Category: Kumar, R]]

[[Category: White, S P]]

[[Category: Oxygen transport]]