1bgf

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[[Image:1bgf.gif|left|200px]]
 
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==STAT-4 N-DOMAIN==
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The line below this paragraph, containing "STRUCTURE_1bgf", creates the "Structure Box" on the page.
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<StructureSection load='1bgf' size='340' side='right'caption='[[1bgf]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bgf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgf OCA], [https://pdbe.org/1bgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgf RCSB], [https://www.ebi.ac.uk/pdbsum/1bgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgf ProSAT]</span></td></tr>
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{{STRUCTURE_1bgf| PDB=1bgf | SCENE= }}
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</table>
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== Function ==
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'''STAT-4 N-DOMAIN'''
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[https://www.uniprot.org/uniprot/STAT4_MOUSE STAT4_MOUSE] Carries out a dual function: signal transduction and activation of transcription.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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STATs (signal transducers and activators of transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. The crystal structure of an NH2-terminal conserved domain (N-domain) comprising the first 123 residues of STAT-4 was determined at 1.45 angstroms. The domain consists of eight helices that are assembled into a hook-like structure. The N-domain has been implicated in several protein-protein interactions affecting transcription, and it enables dimerized STAT molecules to polymerize and to bind DNA cooperatively. The structure shows that N-domains can interact through an extensive interface formed by polar interactions across one face of the hook. Mutagenesis of an invariant tryptophan residue at the heart of this interface abolished cooperative DNA binding by the full-length protein in vitro and reduced the transcriptional response after cytokine stimulation in vivo.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/1bgf_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1BGF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGF OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bgf ConSurf].
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Structure of the amino-terminal protein interaction domain of STAT-4., Vinkemeier U, Moarefi I, Darnell JE Jr, Kuriyan J, Science. 1998 Feb 13;279(5353):1048-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9461439 9461439]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Darnell JE]]
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[[Category: Darnell, J E.]]
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[[Category: Kuriyan J]]
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[[Category: Kuriyan, J.]]
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[[Category: Moarefi I]]
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[[Category: Moarefi, I.]]
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[[Category: Vinkemeier U]]
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[[Category: Vinkemeier, U.]]
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[[Category: Dna-binding]]
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[[Category: Regulation]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:28:54 2008''
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Current revision

STAT-4 N-DOMAIN

PDB ID 1bgf

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