This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5rk0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5rk0 is ON HOLD Authors: Grosjean, H., Aimon, A., Krojer, T., Talon, R., Douangamath, A., Koekemoer, L., Arrowsmith, C.H., Edwards, A., Bountra, C.,...) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z30932204== | |
| + | <StructureSection load='5rk0' size='340' side='right'caption='[[5rk0]], [[Resolution|resolution]] 1.24Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5rk0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5RK0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.24Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T0S:N-[(4-sulfamoylphenyl)methyl]acetamide'>T0S</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5rk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rk0 OCA], [https://pdbe.org/5rk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5rk0 RCSB], [https://www.ebi.ac.uk/pdbsum/5rk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5rk0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Aimon | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Biggin | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Aimon A]] |
| - | [[Category: Edwards | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Biggin PC]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Douangamath A]] |
| - | [[Category: | + | [[Category: Edwards A]] |
| - | [[Category: | + | [[Category: Grosjean H]] |
| + | [[Category: Koekemoer L]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Talon R]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z30932204
| |||||||||||
Categories: Homo sapiens | Large Structures | Aimon A | Arrowsmith CH | Biggin PC | Bountra C | Douangamath A | Edwards A | Grosjean H | Koekemoer L | Krojer T | Talon R | Von Delft F
