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7c8p
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7c8p is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural and functional characterization of human group A rotavirus P[25] VP8*== | |
| + | <StructureSection load='7c8p' size='340' side='right'caption='[[7c8p]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7c8p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus_A Rotavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C8P FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c8p OCA], [https://pdbe.org/7c8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c8p RCSB], [https://www.ebi.ac.uk/pdbsum/7c8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c8p ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/M1GR78_9VIRU M1GR78_9VIRU] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Rotavirus (RV) is a common cause of acute gastroenteritis in young children. While P[8] and P[4] are the most prevalent RV genotypes in humans, other genotypes are also reported in human infections occasionally, including human P[25]. The glycan binding and structural characteristics of human P[25] were explored in our study. Human P[25] VP8* recognized type A histo-blood group antigen (HBGA) in the glycan microarray/oligosaccharide binding assay and could specifically hemagglutinate type A blood cells. Moreover, the P[25] VP8* structure was determined at 2.6 A, revealing a similar conformation and a conserved putative glycan binding site as that of P[14] VP8*. This study provided further knowledge of the glycan binding and structural features of P[25] RV VP8*, promoting our understanding of the infection, prevalence, and host range of the P[III] RVs. | ||
| - | + | Human group A rotavirus P[25] VP8* specifically binds to A-type histo-blood group antigen.,Li D, Wang M, Qi J, Zhang Q, Wang H, Pang L, Sun X, Duan Z Virology. 2021 Mar;555:56-63. doi: 10.1016/j.virol.2020.12.016. Epub 2021 Jan 5. PMID:33453651<ref>PMID:33453651</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7c8p" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rotavirus A]] | ||
| + | [[Category: Dandi L]] | ||
| + | [[Category: Duan Z]] | ||
Current revision
Structural and functional characterization of human group A rotavirus P[25] VP8*
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