1bh9

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[[Image:1bh9.gif|left|200px]]
 
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==HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE WITH BOUND PCMBS==
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The line below this paragraph, containing "STRUCTURE_1bh9", creates the "Structure Box" on the page.
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<StructureSection load='1bh9' size='340' side='right'caption='[[1bh9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bh9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BH9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PMB:PARA-MERCURY-BENZENESULFONIC+ACID'>PMB</scene></td></tr>
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{{STRUCTURE_1bh9| PDB=1bh9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bh9 OCA], [https://pdbe.org/1bh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bh9 RCSB], [https://www.ebi.ac.uk/pdbsum/1bh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bh9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TAF13_HUMAN TAF13_HUMAN] TFIID beta-specific TAFII.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/1bh9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bh9 ConSurf].
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<div style="clear:both"></div>
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'''HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE WITH BOUND PCMBS'''
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==See Also==
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*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Determination of the crystal structure of the human TBP-associated factor (hTAF(II))28/hTAF(II)18 heterodimer shows that these TAF(II)s form a novel histone-like pair in the TFIID complex. The histone folds in hTAF(II)28 and hTAF(II)18 were not predicted from their primary sequence, indicating that these TAF(II)s define a novel family of atypical histone fold sequences. The TAF(II)18 and TAF(II)28 histone fold motifs are also present in the N- and C-terminal regions of the SPT3 proteins, suggesting that the histone fold in SPT3 may be reconstituted by intramolecular rather than classical intermolecular interactions. The existence of additional histone-like pairs in both the TFIID and SAGA complexes shows that the histone fold is a more commonly used motif for mediating TAF-TAF interactions than previously believed.
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==About this Structure==
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1BH9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BH9 OCA].
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==Reference==
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Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family., Birck C, Poch O, Romier C, Ruff M, Mengus G, Lavigne AC, Davidson I, Moras D, Cell. 1998 Jul 24;94(2):239-49. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9695952 9695952]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Birck, C.]]
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[[Category: Birck C]]
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[[Category: Davidson, I.]]
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[[Category: Davidson I]]
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[[Category: Lavigne, A C.]]
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[[Category: Lavigne A-C]]
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[[Category: Mengus, G.]]
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[[Category: Mengus G]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Poch, O.]]
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[[Category: Poch O]]
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[[Category: Romier, C.]]
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[[Category: Romier C]]
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[[Category: Ruff, M.]]
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[[Category: Ruff M]]
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[[Category: Histone fold]]
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[[Category: Htafii18]]
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[[Category: Tata binding protein]]
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[[Category: Transcription regulation complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:30:42 2008''
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Current revision

HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE WITH BOUND PCMBS

PDB ID 1bh9

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