2qil

<table><tr><td colspan='2'>[[2qil]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2QIL FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2qil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qil OCA], [http://pdbe.org/2qil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qil RCSB], [http://www.ebi.ac.uk/pdbsum/2qil PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qil ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU]] Responsible for the symptoms of toxic shock syndrome.

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== Publication Abstract from PubMed ==

The pyrogenic toxin toxic shock syndrome toxin-1 from Staphylococcus aureus is a causative agent of the toxic shock syndrome disease. It belongs to a family of proteins known as superantigens that cross-link major histocompatibility class II molecules and T-cell receptors leading to the activation of a substantial number of T cells. The crystal structure of this protein has been refined to 2.07 A with an Rcryst value of 20.4% for 51,240 reflections. The final model contains three molecules in the asymmetric unit with good stereochemistry and a root-mean-square deviation of 0.009 A and 1.63 from ideality for bond lengths and bond angles, respectively. The overall fold is considerably similar to that of other known microbial superantigens (staphylococcal enterotoxins). However, a detailed structural analysis shows that toxic shock syndrome toxin-1 lacks several structural features that affect its specificity for V beta elements of the T-cell receptor and also its recognition by major histocompatibility class II molecules.

The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution.,Papageorgiou AC, Brehm RD, Leonidas DD, Tranter HS, Acharya KR J Mol Biol. 1996 Jul 26;260(4):553-69. PMID:8759320<ref>PMID:8759320</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Acharya, K R]]

[[Category: Papageorgiou, A C]]

[[Category: Toxic shock syndrome toxin]]