2ran

<table><tr><td colspan='2'>[[2ran]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2RAN FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ran FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ran OCA], [http://pdbe.org/2ran PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ran RCSB], [http://www.ebi.ac.uk/pdbsum/2ran PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ran ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/ANXA5_RAT ANXA5_RAT]] This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

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== Publication Abstract from PubMed ==

Annexins are a family of calcium- and phospholipid-binding proteins implicated in mediating membrane-related processes such as secretion, signal transduction, and ion channel activity. The crystal structure of rat annexin V was solved to 1.9 angstrom resolution by multiple isomorphous replacement. Unlike previously solved annexin V structures, all four domains bound calcium in this structure. Calcium binding in the third domain induced a large relocation of the calcium-binding loop regions, exposing the single tryptophan residue to the solvent. These alterations in annexin V suggest a role for domain 3 in calcium-triggered interaction with phospholipid membranes.

Rat annexin V crystal structure: Ca(2+)-induced conformational changes.,Concha NO, Head JF, Kaetzel MA, Dedman JR, Seaton BA Science. 1993 Sep 3;261(5126):1321-4. PMID:8362244<ref>PMID:8362244</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Buffalo rat]]

[[Category: Concha, N O]]

[[Category: Dedman, J R]]

[[Category: Head, J F]]

[[Category: Kaetzel, M A]]

[[Category: Seaton, B A]]

[[Category: Calcium-phospholipid-binding protein complex]]

[[Category: Calcium/phospholipid-binding protein]]