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5j7e

From Proteopedia

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Current revision (10:52, 6 September 2023) (edit) (undo)
 
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<StructureSection load='5j7e' size='340' side='right'caption='[[5j7e]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5j7e' size='340' side='right'caption='[[5j7e]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J7E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J7E FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNH1, EAG, EAG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7e OCA], [http://pdbe.org/5j7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j7e RCSB], [http://www.ebi.ac.uk/pdbsum/5j7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7e OCA], [https://pdbe.org/5j7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j7e RCSB], [https://www.ebi.ac.uk/pdbsum/5j7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7e ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN]] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]<ref>PMID:22732247</ref> <ref>PMID:23881642</ref> <ref>PMID:9738473</ref>
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[https://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]<ref>PMID:22732247</ref> <ref>PMID:23881642</ref> <ref>PMID:9738473</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Juan, S]]
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[[Category: Juan S]]
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[[Category: Xiaohong, Q]]
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[[Category: Xiaohong Q]]
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[[Category: Xue, T]]
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[[Category: Xue T]]
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[[Category: Ether-a-go-go channel]]
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[[Category: Kcnh channel]]
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[[Category: Pas domain]]
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[[Category: Transport protein]]
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Current revision

hEAG PAS domain

PDB ID 5j7e

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