5j8r

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Current revision (10:54, 6 September 2023) (edit) (undo)
 
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<StructureSection load='5j8r' size='340' side='right'caption='[[5j8r]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
<StructureSection load='5j8r' size='340' side='right'caption='[[5j8r]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j8r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J8R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j8r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J8R FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.043&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8r OCA], [https://pdbe.org/5j8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j8r RCSB], [https://www.ebi.ac.uk/pdbsum/5j8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8r OCA], [http://pdbe.org/5j8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8r RCSB], [http://www.ebi.ac.uk/pdbsum/5j8r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8r ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTN12_HUMAN PTN12_HUMAN]] Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.<ref>PMID:17329398</ref>
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[https://www.uniprot.org/uniprot/PTN12_HUMAN PTN12_HUMAN] Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.<ref>PMID:17329398</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Li H]]
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[[Category: Li, H]]
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[[Category: Sun JP]]
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[[Category: Sun, J P]]
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[[Category: Wang WJ]]
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[[Category: Wang, W J]]
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[[Category: Xiao P]]
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[[Category: Xiao, P]]
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[[Category: Xu YF]]
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[[Category: Xu, Y F]]
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[[Category: Yang F]]
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[[Category: Yang, F]]
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[[Category: Yu X]]
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[[Category: Yu, X]]
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[[Category: Cancer]]
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[[Category: Hydrolase]]
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[[Category: Tyrosine phosphorylation]]
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Current revision

Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant

PDB ID 5j8r

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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