5jkk
From Proteopedia
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<StructureSection load='5jkk' size='340' side='right'caption='[[5jkk]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='5jkk' size='340' side='right'caption='[[5jkk]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5jkk]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5jkk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JKK FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jkk OCA], [https://pdbe.org/5jkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jkk RCSB], [https://www.ebi.ac.uk/pdbsum/5jkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jkk ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Protein containers are suitable building blocks for bioinorganic materials. Here, we show that high concentrations of magnesium ions induce the formation of a unitary protein scaffold, whereas low magnesium concentration leads to a binary protein scaffold. The molecular interactions in the protein scaffold were characterized with X-ray crystallography to high resolution. We show that the unitary framework can be applied for the assembly of inorganic nanoparticles such as metal oxides into highly ordered bioinorganic structures. Our work emphasizes the structural tunability of protein-container-based materials, important for adjusting emerging properties of such materials. | ||
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| + | Metal-Assisted Assembly of Protein Containers Loaded with Inorganic Nanoparticles.,Kunzle M, Eckert T, Beck T Inorg Chem. 2018 Nov 5;57(21):13431-13436. doi: 10.1021/acs.inorgchem.8b01995., Epub 2018 Oct 15. PMID:30351078<ref>PMID:30351078</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5jkk" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Ferritin 3D structures|Ferritin 3D structures]] | *[[Ferritin 3D structures|Ferritin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Beck | + | [[Category: Beck T]] |
| - | [[Category: Kuenzle | + | [[Category: Kuenzle M]] |
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Current revision
Crystal structure of the negatively supercharged variant Ftn(neg) of human heavy chain ferritin
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