Limonene-1,2-epoxide hydrolase

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== Structural highlights ==
== Structural highlights ==
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The complex of LEH with the valpromide inhibitor shows the valpromide in the LEH active site forming a <scene name='84/846725/Cv/3'>hydrogen bond network</scene>. Water molecule is shown as red sphere.In the LEH hydrolysis mechanism <scene name='84/846725/Cv/4'>residue Asp101 acts as the acid and Asp132 as the base</scene> <ref>PMID:26032250</ref>.
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The complex of LEH with the valpromide inhibitor shows the valpromide in the LEH active site forming a <scene name='84/846725/Cv/6'>hydrogen bond network</scene>. Water molecule is shown as red sphere. In the LEH hydrolysis mechanism <scene name='84/846725/Cv/4'>residue Asp101 acts as the acid and Asp132 as the base</scene> <ref>PMID:26032250</ref>.
</StructureSection>
</StructureSection>
==3D structures of limonene-1,2-epoxide hydrolase==
==3D structures of limonene-1,2-epoxide hydrolase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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See [[Epoxide hydrolase]]
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[[1nww]] - ReLEH - ''Rhodococcus erythropolis''<br />
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[[4xbw]], [[5cf1]], [[5cf2]], [[4xbx]], [[5jpp]] - ReLEH (mutant)<br />
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[[4xby]], [[5ck6]], [[5yqt]], [[5yng]] - ReLEH (mutant) + cyclopentene oxide<br />
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[[5gkw]] - ReLEH (mutant) + cyclopentanediol<br />
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[[4xdv]], [[4xbt]], [[5clk]], [[5jpu]] - ReLEH (mutant) + cyclohexanediol<br />
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[[1nu3]] - ReLEH (mutant) + valpromide<br />
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[[5yao]] - ReLEH (mutant) + expoxid<br />
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[[4r9k]], [[4r9l]] - ReLEH (mutant) + hydroxyhexanamide<br />
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[[5aih]], [[5aif]], [[5aii]] - mlLEH - metagenomic library<br />
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[[5aig]] - mlLEH + valpromide <br />
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== References ==
== References ==

Current revision

Se-Met limonene-1,2-epoxide hydrolase complex with inhibitor valpromide and MES (PDB code 1nu3)

Drag the structure with the mouse to rotate

3D structures of limonene-1,2-epoxide hydrolase

See Epoxide hydrolase

References

  1. ↑ Hopmann KH, Hallberg BM, Himo F. Catalytic mechanism of limonene epoxide hydrolase, a theoretical study. J Am Chem Soc. 2005 Oct 19;127(41):14339-47. doi: 10.1021/ja050940p. PMID:16218628 doi:http://dx.doi.org/10.1021/ja050940p
  2. ↑ Arand M, Hallberg BM, Zou J, Bergfors T, Oesch F, van der Werf MJ, de Bont JA, Jones TA, Mowbray SL. Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site. EMBO J. 2003 Jun 2;22(11):2583-92. PMID:12773375 doi:http://dx.doi.org/10.1093/emboj/cdg275
  3. ↑ Ferrandi EE, Sayer C, Isupov MN, Annovazzi C, Marchesi C, Iacobone G, Peng X, Bonch-Osmolovskaya E, Wohlgemuth R, Littlechild JA, Monti D. Discovery and characterization of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries. FEBS J. 2015 May 29. doi: 10.1111/febs.13328. PMID:26032250 doi:http://dx.doi.org/10.1111/febs.13328

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Alexander Berchansky, Michal Harel

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