6x0n
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin== | |
| + | <StructureSection load='6x0n' size='340' side='right'caption='[[6x0n]], [[Resolution|resolution]] 10.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6x0n]] is a 23 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X0N FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x0n OCA], [https://pdbe.org/6x0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x0n RCSB], [https://www.ebi.ac.uk/pdbsum/6x0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x0n ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
| - | + | ==See Also== | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | + | *[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]] | |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Bilokapic S]] | ||
| + | [[Category: Halic M]] | ||
Current revision
Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin
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