6xcg

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(New page: '''Unreleased structure''' The entry 6xcg is ON HOLD Authors: Zhou, M.Q., Dong, A., Ingerman, L.A., Hanley, R.P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genom...)
Current revision (07:44, 23 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6xcg is ON HOLD
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==Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934==
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<StructureSection load='6xcg' size='340' side='right'caption='[[6xcg]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6xcg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XCG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=V01:N-cyclopropyl-3-oxo-N-({4-[(pyrimidin-4-yl)carbamoyl]phenyl}methyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carboxamide'>V01</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcg OCA], [https://pdbe.org/6xcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcg RCSB], [https://www.ebi.ac.uk/pdbsum/6xcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcg ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Wolf-Hirschhorn syndrome. A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH. WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.
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== Function ==
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[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.<ref>PMID:11152655</ref> <ref>PMID:16115125</ref> <ref>PMID:18172012</ref>
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Authors: Zhou, M.Q., Dong, A., Ingerman, L.A., Hanley, R.P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Zhou, M.Q]]
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__TOC__
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[[Category: Min, J]]
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</StructureSection>
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[[Category: Edwards, A.M]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Large Structures]]
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[[Category: Dong, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Bountra C]]
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[[Category: Hanley, R.P]]
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[[Category: Dong A]]
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[[Category: Ingerman, L.A]]
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[[Category: Edwards AM]]
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[[Category: Bountra, C]]
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[[Category: Hanley RP]]
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[[Category: Ingerman LA]]
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[[Category: Min J]]
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[[Category: Zhou MQ]]

Current revision

Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934

PDB ID 6xcg

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