6zbl

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'''Unreleased structure'''
 
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The entry 6zbl is ON HOLD
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==Plasmodium falciparum merozoite surface protein 1 dimer, conformation 2==
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<StructureSection load='6zbl' size='340' side='right'caption='[[6zbl]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6zbl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZBL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zbl OCA], [https://pdbe.org/6zbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zbl RCSB], [https://www.ebi.ac.uk/pdbsum/6zbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zbl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MSP1_PLAF7 MSP1_PLAF7] During the asexual blood stage, involved in merozoite egress from host erythrocytes possibly via its interaction with the host cytoskeleton protein spectrin resulting in the destabilization of the host cytoskeleton and thus leading to erythrocyte cell membrane rupture (PubMed:26468747). Involved in the binding to host erythrocytes and is required for host erythrocyte invasion (PubMed:12692305, PubMed:21175202, PubMed:25778531, PubMed:36202833).<ref>PMID:12692305</ref> <ref>PMID:21175202</ref> <ref>PMID:25778531</ref> <ref>PMID:26468747</ref> <ref>PMID:36202833</ref> By binding to host proinflammatory cytokine S100P may interfere with host immune responses.<ref>PMID:22431641</ref> Involved in merozoite invasion of host erythrocytes (PubMed:1694225, PubMed:29511044). May play a role in the biogenesis and/or function of the food vacuole during the intraerythrocytic development (Probable).<ref>PMID:1694225</ref> <ref>PMID:29511044</ref> <ref>PMID:18769730</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The merozoite surface protein 1 (MSP-1) is the most abundant protein on the surface of the erythrocyte-invading Plasmodium merozoite, the causative agent of malaria. MSP-1 is essential for merozoite formation, entry into and escape from erythrocytes, and is a promising vaccine candidate. Here, we present monomeric and dimeric structures of full-length MSP-1. MSP-1 adopts an unusual fold with a large central cavity. Its fold includes several coiled-coils and shows structural homology to proteins associated with membrane and cytoskeleton interactions. MSP-1 formed dimers through these domains in a concentration-dependent manner. Dimerization is affected by the presence of the erythrocyte cytoskeleton protein spectrin, which may compete for the dimerization interface. Our work provides structural insights into the possible mode of interaction of MSP-1 with erythrocytes and establishes a framework for future investigations into the role of MSP-1 in Plasmodium infection and immunity.
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Authors:
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Structure of the merozoite surface protein 1 from Plasmodium falciparum.,Dijkman PM, Marzluf T, Zhang Y, Chang SS, Helm D, Lanzer M, Bujard H, Kudryashev M Sci Adv. 2021 Jun 2;7(23):eabg0465. doi: 10.1126/sciadv.abg0465. Print 2021 Jun. PMID:34078606<ref>PMID:34078606</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 6zbl" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum]]
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[[Category: Dijkman PM]]
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[[Category: Kudryashev M]]

Current revision

Plasmodium falciparum merozoite surface protein 1 dimer, conformation 2

PDB ID 6zbl

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