6zbz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling== | |
| - | + | <StructureSection load='6zbz' size='340' side='right'caption='[[6zbz]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6zbz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZBZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QE5:2-[(3,4-dimethylphenyl)sulfonylamino]-5-fluoranyl-benzoic+acid'>QE5</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zbz OCA], [https://pdbe.org/6zbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zbz RCSB], [https://www.ebi.ac.uk/pdbsum/6zbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zbz ProSAT]</span></td></tr> |
| - | [[Category: Heinemann | + | </table> |
| - | [[Category: Roske | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Heinemann U]] | ||
| + | [[Category: Oschkinat H]] | ||
| + | [[Category: Roske Y]] | ||
Current revision
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
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