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2uuh

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<StructureSection load='2uuh' size='340' side='right'caption='[[2uuh]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='2uuh' size='340' side='right'caption='[[2uuh]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2uuh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UUH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2uuh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UUH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LMU:DODECYL-ALPHA-D-MALTOSIDE'>LMU</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uui|2uui]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LMU:DODECYL-ALPHA-D-MALTOSIDE'>LMU</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-C(4)_synthase Leukotriene-C(4) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uuh OCA], [https://pdbe.org/2uuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uuh RCSB], [https://www.ebi.ac.uk/pdbsum/2uuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uuh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2uuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uuh OCA], [http://pdbe.org/2uuh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uuh RCSB], [http://www.ebi.ac.uk/pdbsum/2uuh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uuh ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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== Function ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Eshaghi, S]]
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[[Category: Eshaghi S]]
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[[Category: Haeggstrom, J Z]]
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[[Category: Haeggstrom JZ]]
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[[Category: Hammarberg, T]]
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[[Category: Hammarberg T]]
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[[Category: Kohl, A]]
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[[Category: Kohl A]]
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[[Category: McCarthy, A A]]
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[[Category: Martinez Molina D]]
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[[Category: Molina, D Martinez]]
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[[Category: McCarthy AA]]
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[[Category: Niegowski, D]]
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[[Category: Niegowski D]]
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[[Category: Nordlund, P]]
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[[Category: Nordlund P]]
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[[Category: Ohlson, E]]
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[[Category: Ohlson E]]
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[[Category: Wetterholm, A]]
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[[Category: Wetterholm A]]
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[[Category: Eicosanoid]]
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[[Category: Enzyme]]
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[[Category: Glutathione]]
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[[Category: Leukotriene biosynthesis]]
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[[Category: Leukotriene signalling]]
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[[Category: Ltc4]]
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[[Category: Lyase]]
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[[Category: Mapeg]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Transmembrane]]
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[[Category: Trimer]]
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Current revision

Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione

PDB ID 2uuh

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