2v61

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<StructureSection load='2v61' size='340' side='right'caption='[[2v61]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2v61' size='340' side='right'caption='[[2v61]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V61 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V61 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V61 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C18:7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE'>C18</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gos|1gos]], [[1h8r|1h8r]], [[1oj9|1oj9]], [[1oja|1oja]], [[1ojb|1ojb]], [[1ojc|1ojc]], [[1ojd|1ojd]], [[1s2q|1s2q]], [[1s2y|1s2y]], [[1s3b|1s3b]], [[1s3e|1s3e]], [[2bk3|2bk3]], [[2bk4|2bk4]], [[2bk5|2bk5]], [[2byb|2byb]], [[2c64|2c64]], [[2c65|2c65]], [[2c66|2c66]], [[2c67|2c67]], [[2c70|2c70]], [[2c72|2c72]], [[2c73|2c73]], [[2c75|2c75]], [[2c76|2c76]], [[2v5z|2v5z]], [[2v60|2v60]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C18:7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE'>C18</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v61 OCA], [https://pdbe.org/2v61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v61 RCSB], [https://www.ebi.ac.uk/pdbsum/2v61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v61 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v61 OCA], [http://pdbe.org/2v61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v61 RCSB], [http://www.ebi.ac.uk/pdbsum/2v61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v61 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/2v61_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/2v61_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
*[[Monoamine oxidase|Monoamine oxidase]]
*[[Monoamine oxidase|Monoamine oxidase]]
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*[[User:Eric Martz/JSmol Notes|User:Eric Martz/JSmol Notes]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Monoamine oxidase]]
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[[Category: Binda C]]
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[[Category: Binda, C]]
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[[Category: Caccia C]]
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[[Category: Caccia, C]]
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[[Category: Carotti A]]
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[[Category: Carotti, A]]
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[[Category: Edmondson DE]]
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[[Category: Edmondson, D E]]
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[[Category: Mattevi A]]
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[[Category: Mattevi, A]]
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[[Category: Pisani L]]
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[[Category: Pisani, L]]
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[[Category: Salvati P]]
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[[Category: Salvati, P]]
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[[Category: Wang J]]
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[[Category: Wang, J]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Human mao b structure]]
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[[Category: Membrane]]
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[[Category: Mitochondrion]]
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[[Category: Neuroprotection]]
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[[Category: Oxidoreductase]]
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[[Category: Parkinson's disease]]
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[[Category: Reversible inhibitor binding]]
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[[Category: Safinamide]]
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[[Category: Transmembrane]]
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Current revision

Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin

PDB ID 2v61

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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