1bn0

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(New page: 200px<br /> <applet load="1bn0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bn0" /> '''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HI...)
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[[Image:1bn0.gif|left|200px]]<br />
 
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<applet load="1bn0" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bn0" />
 
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'''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES'''<br />
 
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==Overview==
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==SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES==
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An NMR-based structure is presented for a 20 mer hairpin model of the SL3, stem-loop from the HIV-1 packaging signal. The stem has an A-family, structure. However, the GGAG tetraloop appears to be flexible with the, second (G10) and fourth (G12) bases extruded from the normal stacking, arrangement. The A-base (A11) occupies a cavity large enough for it to, jump rapidly between stacking upon G9 (in the loop) and G13 (from the, base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12, are unoccupied in the free RNA structure. The loop should be easily, adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
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<StructureSection load='1bn0' size='340' side='right'caption='[[1bn0]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bn0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BN0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bn0 OCA], [https://pdbe.org/1bn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bn0 RCSB], [https://www.ebi.ac.uk/pdbsum/1bn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bn0 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
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==About this Structure==
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Three-dimensional folding of an RNA hairpin required for packaging HIV-1.,Pappalardo L, Kerwood DJ, Pelczer I, Borer PN J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628<ref>PMID:9743628</ref>
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1BN0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9743628 9743628]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 1bn0" style="background-color:#fffaf0;"></div>
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[[Category: Borer, P.N.]]
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== References ==
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[[Category: Kerwood, D.J.]]
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<references/>
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[[Category: Pappalardo, L.]]
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__TOC__
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[[Category: Pelczer, I.]]
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</StructureSection>
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[[Category: hiv-1]]
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[[Category: Large Structures]]
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[[Category: nmr]]
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[[Category: Borer PN]]
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[[Category: packaging]]
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[[Category: Kerwood DJ]]
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[[Category: ribonucleic acid]]
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[[Category: Pappalardo L]]
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[[Category: rna]]
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[[Category: Pelczer I]]
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[[Category: tetraloop]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov 8 13:54:10 2007''
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Current revision

SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES

PDB ID 1bn0

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