1bnz

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[[Image:1bnz.gif|left|200px]]
 
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==SSO7D HYPERTHERMOPHILE PROTEIN/DNA COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1bnz", creates the "Structure Box" on the page.
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<StructureSection load='1bnz' size='340' side='right'caption='[[1bnz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bnz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BNZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bnz OCA], [https://pdbe.org/1bnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bnz RCSB], [https://www.ebi.ac.uk/pdbsum/1bnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bnz ProSAT]</span></td></tr>
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{{STRUCTURE_1bnz| PDB=1bnz | SCENE= }}
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</table>
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== Function ==
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'''SSO7D HYPERTHERMOPHILE PROTEIN/DNA COMPLEX'''
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[https://www.uniprot.org/uniprot/DN7D_SACS2 DN7D_SACS2] Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature (By similarity). Stimulates the Holliday junction cleavage activity of Hjc (PubMed:11709558).[UniProtKB:P61990]<ref>PMID:11709558</ref>
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== References ==
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<references/>
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==Overview==
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__TOC__
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Sso7d and Sac7d are two small (approximately 7,000 Mr), but abundant, chromosomal proteins from the hyperthermophilic archaeabacteria Sulfolobus solfataricus and S. acidocaldarius respectively. These proteins have high thermal, acid and chemical stability. They bind DNA without marked sequence preference and increase the Tm of DNA by approximately 40 degrees C. Sso7d in complex with GTAATTAC and GCGT(iU)CGC + GCGAACGC was crystallized in different crystal lattices and the crystal structures were solved at high resolution. Sso7d binds in the minor groove of DNA and causes a single-step sharp kink in DNA (approximately 60 degrees) by the intercalation of the hydrophobic side chains of Val 26 and Met 29. The intercalation sites are different in the two complexes. Observations of this novel DNA binding mode in three independent crystal lattices indicate that it is not a function of crystal packing.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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1BNZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNZ OCA].
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==Reference==
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The crystal structure of the hyperthermophile chromosomal protein Sso7d bound to DNA., Gao YG, Su SY, Robinson H, Padmanabhan S, Lim L, McCrary BS, Edmondson SP, Shriver JW, Wang AH, Nat Struct Biol. 1998 Sep;5(9):782-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9731772 9731772]
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[[Category: Single protein]]
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[[Category: Sulfolobus acidocaldarius]]
[[Category: Sulfolobus acidocaldarius]]
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[[Category: Edmondos, S P.]]
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[[Category: Edmondos SP]]
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[[Category: Gao, Y G.]]
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[[Category: Gao Y-G]]
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[[Category: Lim, L.]]
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[[Category: Lim L]]
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[[Category: Mccrary, B S.]]
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[[Category: Mccrary BS]]
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[[Category: Padmanabhan, S.]]
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[[Category: Padmanabhan S]]
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[[Category: Robinson, H.]]
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[[Category: Robinson H]]
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[[Category: Shrive, J W.]]
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[[Category: Shrive JW]]
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[[Category: Su, S Y.]]
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[[Category: Su S-Y]]
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[[Category: Wang, A H.J.]]
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[[Category: Wang AH-J]]
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[[Category: Protein-dna interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:45:08 2008''
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Current revision

SSO7D HYPERTHERMOPHILE PROTEIN/DNA COMPLEX

PDB ID 1bnz

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