1bpw

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[[Image:1bpw.gif|left|200px]]
 
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==BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER==
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The line below this paragraph, containing "STRUCTURE_1bpw", creates the "Structure Box" on the page.
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<StructureSection load='1bpw' size='340' side='right'caption='[[1bpw]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bpw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gadus_morhua_callarias Gadus morhua callarias]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BPW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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{{STRUCTURE_1bpw| PDB=1bpw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpw OCA], [https://pdbe.org/1bpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bpw RCSB], [https://www.ebi.ac.uk/pdbsum/1bpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bpw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AL9A1_GADMC AL9A1_GADMC]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/1bpw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bpw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of betaine aldehyde dehydrogenase, the most abundant aldehyde dehydrogenase (ALDH) of cod liver, has been determined at 2.1 A resolution by the X-ray crystallographic method of molecular replacement. This enzyme represents a novel structure of the highly multiple ALDH, with at least 12 distinct classes in humans. This betaine ALDH of class 9 is different from the two recently determined ALDH structures (classes 2 and 3). Like these, the betaine ALDH structure has three domains, one coenzyme binding domain, one catalytic domain, and one oligomerization domain. Crystals grown in the presence or absence of NAD+ have very similar structures and no significant conformational change occurs upon coenzyme binding. This is probably due to the tight interactions between domains within the subunit and between subunits in the tetramer. The oligomerization domains link the catalytic domains together into two 20-stranded pleated sheet structures. The overall structure is similar to that of the tetrameric bovine class 2 and dimeric rat class 3 ALDH, but the coenzyme binding with the nicotinamide in anti conformation, resembles that of class 2 rather than of class 3.
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'''BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER'''
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Structure of betaine aldehyde dehydrogenase at 2.1 A resolution.,Johansson K, El-Ahmad M, Ramaswamy S, Hjelmqvist L, Jornvall H, Eklund H Protein Sci. 1998 Oct;7(10):2106-17. PMID:9792097<ref>PMID:9792097</ref>
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==Overview==
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The three-dimensional structure of betaine aldehyde dehydrogenase, the most abundant aldehyde dehydrogenase (ALDH) of cod liver, has been determined at 2.1 A resolution by the X-ray crystallographic method of molecular replacement. This enzyme represents a novel structure of the highly multiple ALDH, with at least 12 distinct classes in humans. This betaine ALDH of class 9 is different from the two recently determined ALDH structures (classes 2 and 3). Like these, the betaine ALDH structure has three domains, one coenzyme binding domain, one catalytic domain, and one oligomerization domain. Crystals grown in the presence or absence of NAD+ have very similar structures and no significant conformational change occurs upon coenzyme binding. This is probably due to the tight interactions between domains within the subunit and between subunits in the tetramer. The oligomerization domains link the catalytic domains together into two 20-stranded pleated sheet structures. The overall structure is similar to that of the tetrameric bovine class 2 and dimeric rat class 3 ALDH, but the coenzyme binding with the nicotinamide in anti conformation, resembles that of class 2 rather than of class 3.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1BPW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gadus_callarias Gadus callarias]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPW OCA].
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</div>
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<div class="pdbe-citations 1bpw" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structure of betaine aldehyde dehydrogenase at 2.1 A resolution., Johansson K, El-Ahmad M, Ramaswamy S, Hjelmqvist L, Jornvall H, Eklund H, Protein Sci. 1998 Oct;7(10):2106-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9792097 9792097]
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
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[[Category: Betaine-aldehyde dehydrogenase]]
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== References ==
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[[Category: Gadus callarias]]
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<references/>
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[[Category: Single protein]]
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__TOC__
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[[Category: Ahmad, M El.]]
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</StructureSection>
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[[Category: Eklund, H.]]
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[[Category: Gadus morhua callarias]]
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[[Category: Hjelmqvist, L.]]
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[[Category: Large Structures]]
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[[Category: Johansson, K.]]
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[[Category: Eklund H]]
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[[Category: Jornvall, H.]]
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[[Category: El Ahmad M]]
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[[Category: Ramaswamy, S.]]
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[[Category: Hjelmqvist L]]
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[[Category: Aldehyde oxidation]]
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[[Category: Johansson K]]
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[[Category: Nad complex]]
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[[Category: Jornvall H]]
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[[Category: Oxidoreductase]]
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[[Category: Ramaswamy S]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:48:40 2008''
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Current revision

BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER

PDB ID 1bpw

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