1bqj

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[[Image:1bqj.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF D(ACCCT)==
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The line below this paragraph, containing "STRUCTURE_1bqj", creates the "Structure Box" on the page.
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<StructureSection load='1bqj' size='340' side='right'caption='[[1bqj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bqj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BQJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqj OCA], [https://pdbe.org/1bqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bqj RCSB], [https://www.ebi.ac.uk/pdbsum/1bqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bqj ProSAT]</span></td></tr>
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{{STRUCTURE_1bqj| PDB=1bqj | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''CRYSTAL STRUCTURE OF D(ACCCT)'''
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== Publication Abstract from PubMed ==
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==Overview==
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The crystal structure of d(ACCCT), solved by molecular replacement, shows a four-stranded i-motif conformation, where two parallel duplexes intercalate with one another in opposite orientations. Each duplex is stabilized by hemi-protonated C-C+ base pairing between parallel strands, and a string of water molecules bridge the cytosine N4 atoms to phosphate O atoms. This structure of d(ACCCT) shows examples of reversed Hoogsteen and Watson-Crick base pairing in both intermolecular and intramolecular manners to stabilize the tetraplex. Noticeably, the four-stranded complex is further stabilized at one end by a three-base hydrogen-bonding network, in which two adenines and a thymine form four hydrogen bonds via a reverse Hoogsteen and an asymmetric adenine-adenine base pairing. The structure of d(ACCCT) shows a similar local structure to that found in the d(TAA) part of the crystal structure of d(TAACCC) and provides further structural evidence that these base arrangements are essential for stabilizing these novel DNA super-secondary structures.
The crystal structure of d(ACCCT), solved by molecular replacement, shows a four-stranded i-motif conformation, where two parallel duplexes intercalate with one another in opposite orientations. Each duplex is stabilized by hemi-protonated C-C+ base pairing between parallel strands, and a string of water molecules bridge the cytosine N4 atoms to phosphate O atoms. This structure of d(ACCCT) shows examples of reversed Hoogsteen and Watson-Crick base pairing in both intermolecular and intramolecular manners to stabilize the tetraplex. Noticeably, the four-stranded complex is further stabilized at one end by a three-base hydrogen-bonding network, in which two adenines and a thymine form four hydrogen bonds via a reverse Hoogsteen and an asymmetric adenine-adenine base pairing. The structure of d(ACCCT) shows a similar local structure to that found in the d(TAA) part of the crystal structure of d(TAACCC) and provides further structural evidence that these base arrangements are essential for stabilizing these novel DNA super-secondary structures.
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==About this Structure==
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Stabilization of the i-motif by intramolecular adenine-adenine-thymine base triple in the structure of d(ACCCT).,Weil J, Min T, Yang C, Wang S, Sutherland C, Sinha N, Kang C Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):422-9. PMID:10089350<ref>PMID:10089350</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQJ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Stabilization of the i-motif by intramolecular adenine-adenine-thymine base triple in the structure of d(ACCCT)., Weil J, Min T, Yang C, Wang S, Sutherland C, Sinha N, Kang C, Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):422-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10089350 10089350]
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</div>
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[[Category: Kang, C H.]]
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<div class="pdbe-citations 1bqj" style="background-color:#fffaf0;"></div>
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[[Category: Min, T.]]
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== References ==
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[[Category: Sinha, N.]]
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<references/>
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[[Category: Sutherland, C.]]
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__TOC__
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[[Category: Wang, S.]]
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</StructureSection>
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[[Category: Weil, J.]]
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[[Category: Large Structures]]
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[[Category: Yang, C.]]
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[[Category: Kang CH]]
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[[Category: Human telomeric fragment]]
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[[Category: Min T]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:50:04 2008''
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[[Category: Sinha N]]
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[[Category: Sutherland C]]
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[[Category: Wang S]]
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[[Category: Weil J]]
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[[Category: Yang C]]

Current revision

CRYSTAL STRUCTURE OF D(ACCCT)

PDB ID 1bqj

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