6x1k

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'''Unreleased structure'''
 
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The entry 6x1k is ON HOLD until Paper Publication
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==Solution NMR structure of de novo designed TMB2.3==
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<StructureSection load='6x1k' size='340' side='right'caption='[[6x1k]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6x1k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X1K FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x1k OCA], [https://pdbe.org/6x1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x1k RCSB], [https://www.ebi.ac.uk/pdbsum/6x1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x1k ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transmembrane beta-barrel proteins (TMBs) are of great interest for single-molecule analytical technologies because they can spontaneously fold and insert into membranes and form stable pores, but the range of pore properties that can be achieved by repurposing natural TMBs is limited. We leverage the power of de novo computational design coupled with a "hypothesis, design, and test" approach to determine TMB design principles, notably, the importance of negative design to slow beta-sheet assembly. We design new eight-stranded TMBs, with no homology to known TMBs, that insert and fold reversibly into synthetic lipid membranes and have nuclear magnetic resonance and x-ray crystal structures very similar to the computational models. These advances should enable the custom design of pores for a wide range of applications.
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Authors: Liang, B., Vorobieva, A.A., Chow, C.M., Baker, D., Tamm, L.K.
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De novo design of transmembrane beta barrels.,Vorobieva AA, White P, Liang B, Horne JE, Bera AK, Chow CM, Gerben S, Marx S, Kang A, Stiving AQ, Harvey SR, Marx DC, Khan GN, Fleming KG, Wysocki VH, Brockwell DJ, Tamm LK, Radford SE, Baker D Science. 2021 Feb 19;371(6531). pii: 371/6531/eabc8182. doi:, 10.1126/science.abc8182. PMID:33602829<ref>PMID:33602829</ref>
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Description: Solution NMR structure of de novo designed TMB2.3
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Vorobieva, A.A]]
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<div class="pdbe-citations 6x1k" style="background-color:#fffaf0;"></div>
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[[Category: Chow, C.M]]
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== References ==
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[[Category: Baker, D]]
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<references/>
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[[Category: Liang, B]]
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__TOC__
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[[Category: Tamm, L.K]]
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Baker D]]
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[[Category: Chow CM]]
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[[Category: Liang B]]
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[[Category: Tamm LK]]
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[[Category: Vorobieva AA]]

Current revision

Solution NMR structure of de novo designed TMB2.3

PDB ID 6x1k

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