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6xau

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'''Unreleased structure'''
 
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The entry 6xau is ON HOLD until Jun 04 2022
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==Structure of the PR domain from PRDM3==
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<StructureSection load='6xau' size='340' side='right'caption='[[6xau]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6xau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MECOM_MOUSE MECOM_MOUSE] Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.<ref>PMID:15889140</ref> <ref>PMID:18619962</ref> <ref>PMID:19767769</ref> Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.<ref>PMID:22939622</ref>
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Authors: Mou, T.C., Loa, S., Sprang, S.R., Briknarova, K.
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: Structure of the PR domain from PRDM3
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Loa, S]]
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__TOC__
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[[Category: Mou, T.C]]
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</StructureSection>
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[[Category: Briknarova, K]]
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[[Category: Large Structures]]
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[[Category: Sprang, S.R]]
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[[Category: Mus musculus]]
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[[Category: Briknarova K]]
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[[Category: Loa S]]
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[[Category: Mou TC]]
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[[Category: Sprang SR]]

Current revision

Structure of the PR domain from PRDM3

PDB ID 6xau

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