1buy

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[[Image:1buy.gif|left|200px]]
 
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==HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1buy", creates the "Structure Box" on the page.
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<StructureSection load='1buy' size='340' side='right'caption='[[1buy]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1buy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BUY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1buy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1buy OCA], [https://pdbe.org/1buy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1buy RCSB], [https://www.ebi.ac.uk/pdbsum/1buy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1buy ProSAT]</span></td></tr>
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{{STRUCTURE_1buy| PDB=1buy | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/EPO_HUMAN EPO_HUMAN] Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2) [MIM:[https://omim.org/entry/612623 612623]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
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== Function ==
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[https://www.uniprot.org/uniprot/EPO_HUMAN EPO_HUMAN] Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/1buy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1buy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of human erythropoietin (EPO) has been determined by nuclear magnetic resonance spectroscopy and the overall topology of the protein is revealed as a novel combination of features taken from both the long-chain and short-chain families of hematopoietic growth factors. Using the structure and data from mutagenesis studies we have elucidated the key physiochemical properties defining each of the two receptor binding sites on the EPO protein. A comparison of the NMR structure of the free EPO ligand to the receptor bound form, determined by X-ray crystallography, reveals conformational changes that may accompany receptor binding.
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'''HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE'''
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NMR structure of human erythropoietin and a comparison with its receptor bound conformation.,Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS Nat Struct Biol. 1998 Oct;5(10):861-6. PMID:9783743<ref>PMID:9783743</ref>
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==Overview==
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The solution structure of human erythropoietin (EPO) has been determined by nuclear magnetic resonance spectroscopy and the overall topology of the protein is revealed as a novel combination of features taken from both the long-chain and short-chain families of hematopoietic growth factors. Using the structure and data from mutagenesis studies we have elucidated the key physiochemical properties defining each of the two receptor binding sites on the EPO protein. A comparison of the NMR structure of the free EPO ligand to the receptor bound form, determined by X-ray crystallography, reveals conformational changes that may accompany receptor binding.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1BUY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUY OCA].
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</div>
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<div class="pdbe-citations 1buy" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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NMR structure of human erythropoietin and a comparison with its receptor bound conformation., Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS, Nat Struct Biol. 1998 Oct;5(10):861-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9783743 9783743]
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*[[Erythropoietin|Erythropoietin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aoki, K H.]]
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[[Category: Aoki KH]]
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[[Category: Cheetham, J C.]]
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[[Category: Cheetham JC]]
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[[Category: Egrie, J.]]
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[[Category: Egrie J]]
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[[Category: Harvey, T S.]]
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[[Category: Harvey TS]]
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[[Category: Hoeffel, T J.]]
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[[Category: Hoeffel TJ]]
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[[Category: Smith, D M.]]
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[[Category: Smith DM]]
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[[Category: Stevenson, J L.]]
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[[Category: Stevenson JL]]
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[[Category: Syed, R S.]]
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[[Category: Syed RS]]
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[[Category: Cytokine]]
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[[Category: Glycoprotein]]
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[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:59:07 2008''
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HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE

PDB ID 1buy

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