1buz

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[[Image:1buz.jpg|left|200px]]
 
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==SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS NMR, MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1buz", creates the "Structure Box" on the page.
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<StructureSection load='1buz' size='340' side='right'caption='[[1buz]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1buz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BUZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1buz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1buz OCA], [https://pdbe.org/1buz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1buz RCSB], [https://www.ebi.ac.uk/pdbsum/1buz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1buz ProSAT]</span></td></tr>
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{{STRUCTURE_1buz| PDB=1buz | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SP2AA_BACSU SP2AA_BACSU] In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.<ref>PMID:8358793</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/1buz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1buz ConSurf].
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<div style="clear:both"></div>
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'''SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS NMR, MINIMIZED AVERAGE STRUCTURE'''
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==See Also==
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*[[Anti-sigma factor antagonist 3D structures|Anti-sigma factor antagonist 3D structures]]
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== References ==
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==Overview==
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<references/>
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The establishment of differential gene expression in sporulating Bacillus subtilis involves four protein components, one of which, SpoIIAA, undergoes phosphorylation and dephosphorylation. We have used NMR spectroscopy to determine the solution structure of the nonphosphorylated form of SpoIIAA. The structure shows a fold consisting of a four-stranded beta-sheet and four alpha-helices. Knowledge of the structure helps to account for the phenotype of several strains of B. subtilis that carry known spoIIAA mutations and should facilitate investigations of the conformational consequences of phosphorylation.
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__TOC__
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</StructureSection>
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==About this Structure==
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1BUZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUZ OCA].
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==Reference==
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Solution structure of SpoIIAA, a phosphorylatable component of the system that regulates transcription factor sigmaF of Bacillus subtilis., Kovacs H, Comfort D, Lord M, Campbell ID, Yudkin MD, Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5067-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9560229 9560229]
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Campbell, I D.]]
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[[Category: Campbell ID]]
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[[Category: Comfort, D.]]
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[[Category: Comfort D]]
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[[Category: Kovacs, H.]]
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[[Category: Kovacs H]]
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[[Category: Lord, M.]]
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[[Category: Lord M]]
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[[Category: Yudkin, M D.]]
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[[Category: Yudkin MD]]
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[[Category: Anti-anti sigma factor]]
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[[Category: Kinase substrate]]
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[[Category: Novel alpha/beta fold]]
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[[Category: Phosphorylation]]
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[[Category: Sporulation]]
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[[Category: Transcription regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:59:13 2008''
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Current revision

SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1buz

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