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1ggi

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CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN

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Retrieved from "http://52.214.119.220/wiki/index.php/1ggi"

Categories: Large Structures | Mus musculus | Rini JM | Stanfield RL | Wilson IA

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-[[Image:1ggi.gif|left|200px]]<br />
-<applet load="1ggi" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1ggi, resolution 2.8&Aring;" />
-'''CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN'''<br />
-==Overview==
+==CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN==
-The crystal structure of the Fab fragment of a human immunodeficiency, virus type 1 (HIV-1) neutralizing monoclonal antibody Fab has been, determined at 2.8 A resolution in complex with a linear 16-residue peptide, from the third hypervariable region (V3) of gp120. The first 9 residues of, the peptide are ordered in the electron density maps, and their, conformation is in partial agreement with the beta-strand-type II, beta-turn structure predicted for this portion of the V3 loop. Notably, several of the peptide residues that are well conserved among different, HIV-1 isolates contact a nonpolar 25-A-long groove in the, antibody-combining site. The largely extended structure of the peptide, differs from the beta-turns seen as the primary determinants in other, published anti-peptide Fab structures. Analysis of the specific, Fab-peptide interactions only partially explains the MN isolate, specificity shown by this antibody.
+<StructureSection load='1ggi' size='340' side='right'caption='[[1ggi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1ggi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GGI FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ggi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ggi OCA], [https://pdbe.org/1ggi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ggi RCSB], [https://www.ebi.ac.uk/pdbsum/1ggi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ggi ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GCAA_MOUSE GCAA_MOUSE]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/1ggi_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ggi ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-GGI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GGI OCA].
+*[[Antibody 3D structures|Antibody 3D structures]]
+*[[3D structures of non-human antibody|3D structures of non-human antibody]]
-==Reference==
+__TOC__
-Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen., Rini JM, Stanfield RL, Stura EA, Salinas PA, Profy AT, Wilson IA, Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6325-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8327513 8327513]
+</StructureSection>
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Rini, J.M.]]
+[[Category: Mus musculus]]
-[[Category: Stanfield, R.L.]]
+[[Category: Rini JM]]
-[[Category: Wilson, I.A.]]
+[[Category: Stanfield RL]]
-[[Category: immunoglobulin]]
+[[Category: Wilson IA]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 14:04:32 2007''

1ggi

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CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN

Structural highlights

Function

Evolutionary Conservation

See Also

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