6vth

<table><tr><td colspan='2'>[[6vth]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VTH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VTH FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vth OCA], [http://pdbe.org/6vth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vth RCSB], [http://www.ebi.ac.uk/pdbsum/6vth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vth ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Adoptive cell therapy (ACT) with tumor-specific T cells can mediate cancer regression. The main target of tumor-specific T cells are neoantigens arising from mutations in self-proteins. Although the majority of cancer neoantigens are unique to each patient, and therefore not broadly useful for ACT, some are shared. We studied oligoclonal T-cell receptors (TCRs) that recognize a shared neoepitope arising from a driver mutation in the p53 oncogene (p53R175H) presented by HLA-A2. Here we report structures of wild-type and mutant p53-HLA-A2 ligands, as well as structures of three tumor-specific TCRs bound to p53R175H-HLA-A2. These structures reveal how a driver mutation in p53 rendered a self-peptide visible to T cells. The TCRs employ structurally distinct strategies that are highly focused on the mutation to discriminate between mutant and wild-type p53. The TCR-p53R175H-HLA-A2 complexes provide a framework for designing TCRs to improve potency for ACT without sacrificing specificity.

 

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== References ==

[[Category: Human]]

[[Category: Gallagher, D T]]

[[Category: Gowthaman, R]]

[[Category: Mariuzza, R A]]

[[Category: Pierce, B G]]

[[Category: Wu, D]]

[[Category: Tcr complex]]