5k0n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (19:17, 20 September 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5k0n' size='340' side='right'caption='[[5k0n]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='5k0n' size='340' side='right'caption='[[5k0n]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5k0n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5K0N FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5k0n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K0N FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6P0:5-[1-(4-METHOXYPHENYL)CYCLOPROPYL]-1,3-DIMETHYL-1H,2H-3,4-BIPYRAZOLE'>6P0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Comt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6P0:5-[1-(4-METHOXYPHENYL)CYCLOPROPYL]-1,3-DIMETHYL-1H,2H-3,4-BIPYRAZOLE'>6P0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0n OCA], [https://pdbe.org/5k0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k0n RCSB], [https://www.ebi.ac.uk/pdbsum/5k0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0n ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5k0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0n OCA], [http://pdbe.org/5k0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k0n RCSB], [http://www.ebi.ac.uk/pdbsum/5k0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0n ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
+
[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 27: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Buffalo rat]]
 
-
[[Category: Catechol O-methyltransferase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ehler, A]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Rodriguez-Sarmiento, R M]]
+
[[Category: Ehler A]]
-
[[Category: Catechol]]
+
[[Category: Rodriguez-Sarmiento RM]]
-
[[Category: Methyltransferase]]
+
-
[[Category: Neurotransmitter degradation]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal Structure of COMT in complex with 4-[5-[1-(4-methoxyphenyl)cyclopropyl]-1H-pyrazol-3-yl]-1,3-dimethylpyrazole

PDB ID 5k0n

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5k0n"
Personal tools