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CAMP-dependent protein kinase 3D structures
From Proteopedia
(Difference between revisions)
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*PKA catalytic subunit binary complex | *PKA catalytic subunit binary complex | ||
| - | **[[6c0u]] - hPKA + inhibitor<br /> | + | **[[6c0u]], [[7y1g]] - hPKA + inhibitor<br /> |
**[[3agl]], [[3agm]] – hPKA + bisubstrate inhibitor<br /> | **[[3agl]], [[3agm]] – hPKA + bisubstrate inhibitor<br /> | ||
**[[3bwj]] - bPKA + bisubstrate inhibitor<br /> | **[[3bwj]] - bPKA + bisubstrate inhibitor<br /> | ||
**[[1szm]] - bPKA + bisindolymaleimide<br /> | **[[1szm]] - bPKA + bisindolymaleimide<br /> | ||
**[[3ag9]] - bPKA + inhibitor<br /> | **[[3ag9]] - bPKA + inhibitor<br /> | ||
| + | **[[7lz4]] – bPKA (mutant) + CMP<br /> | ||
**[[5n1f]], [[5n1g]], [[5n1h]], [[5n3g]], [[5n3h]], [[5n3i]], [[5n3j]], [[5n3k]], [[5n3l]], [[5n3m]], [[5n3n]], [[5n3o]], [[5n3p]], [[5n3q]], [[5n3r]], [[5n3s]], [[5n3t]] - haPKA + fragment molecule<br /> | **[[5n1f]], [[5n1g]], [[5n1h]], [[5n3g]], [[5n3h]], [[5n3i]], [[5n3j]], [[5n3k]], [[5n3l]], [[5n3m]], [[5n3n]], [[5n3o]], [[5n3p]], [[5n3q]], [[5n3r]], [[5n3s]], [[5n3t]] - haPKA + fragment molecule<br /> | ||
| - | **[[6em2]] - haPKA + | + | **[[6em2]], [[6sq1]] - haPKA + drug<br /> |
| + | **[[6snn]], [[6snx]], [[6sox]], [[6spm]], [[6sps]], [[6spu]], [[6z44]] - haPKA + benzoic acid derivative<br /> | ||
| + | **[[6spy]] - haPKA + pyridine derivative<br /> | ||
| + | **[[6zn0]] - haPKA + nicotinamide derivative<br /> | ||
| + | **[[6z08]], [[7bar]] - haPKA + ligand<br /> | ||
**[[4ntt]] – mPKA (mutant) + ADP<br /> | **[[4ntt]] – mPKA (mutant) + ADP<br /> | ||
**[[1bkx]] – mPKA + adenosine<br /> | **[[1bkx]] – mPKA + adenosine<br /> | ||
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**[[4iac]], [[4iad]], [[4iaf]], [[4iai]], [[4iak]], [[4iay]], [[4iaz]], [[4ib0]] - mPKA + PSP20 peptide<br /> | **[[4iac]], [[4iad]], [[4iaf]], [[4iai]], [[4iak]], [[4iay]], [[4iaz]], [[4ib0]] - mPKA + PSP20 peptide<br /> | ||
**[[4ib1]], [[4ib3]], [[4o22]] – mPKA + SP20 peptide<br /> | **[[4ib1]], [[4ib3]], [[4o22]] – mPKA + SP20 peptide<br /> | ||
| - | **[[6mm5]] – mPKA + | + | **[[6mm5]] – mPKA + ryanodine receptor 2 peptide<br /> |
| - | **[[6mm6]], [[6mm7]], [[6mm8]] – mPKA + | + | **[[6mm6]], [[6mm7]], [[6mm8]] – mPKA + ryanodine receptor 2 phosphorylation domain<br /> |
**[[4wb5]], [[4wb6]], [[4wb8]] – mPKA (mutant) + PKI peptide<br /> | **[[4wb5]], [[4wb6]], [[4wb8]] – mPKA (mutant) + PKI peptide<br /> | ||
**[[4wih]], [[5lcp]], [[5lcq]], [[5lcr]], [[5lct]], [[5lcu]], [[5m0u]] - haPKA + peptide inhibitor <br /> | **[[4wih]], [[5lcp]], [[5lcq]], [[5lcr]], [[5lct]], [[5lcu]], [[5m0u]] - haPKA + peptide inhibitor <br /> | ||
| + | **[[6y2u]], [[6yna]], [[6ynb]], [[6ync]], [[6ynt]], [[6ypp]], [[6yqi]], [[6yqj]], [[6yqk]] – haPKA + PKI peptide + drug<br /> | ||
| + | **[[6y0b]], [[6y2o]], [[6y89]], [[6ynr]], [[6yot]] – haPKA + PKI peptide + inhibitor<br /> | ||
*PKA catalytic subunit ternary complex | *PKA catalytic subunit ternary complex | ||
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**[[2erz]] - mPKA + peptide inhibitor + hydroxyfasudil<br /> | **[[2erz]] - mPKA + peptide inhibitor + hydroxyfasudil<br /> | ||
**[[5mhi]], [[5n1d]], [[5n1e]], [[5n1k]], [[5n1l]], [[5n1m]], [[5n1n]], [[5n1o]], [[5n32]], [[5n33]], [[5n36]], [[5n37]], [[5n39]], [[5n3a]], [[5n3b]], [[5n3c]], [[5n3d]], [[5n3e]], [[5n3f]], [[5n7p]], [[5n7u]] - haPKA + peptide inhibitor + fragment molecule<br /> | **[[5mhi]], [[5n1d]], [[5n1e]], [[5n1k]], [[5n1l]], [[5n1m]], [[5n1n]], [[5n1o]], [[5n32]], [[5n33]], [[5n36]], [[5n37]], [[5n39]], [[5n3a]], [[5n3b]], [[5n3c]], [[5n3d]], [[5n3e]], [[5n3f]], [[5n7p]], [[5n7u]] - haPKA + peptide inhibitor + fragment molecule<br /> | ||
| - | **[[6f14]], [[6frx]], [[6erv]], [[6eru]], [[6ert]], [[6i2h]], [[ | + | **[[6f14]], [[6frx]], [[6erv]], [[6eru]], [[6ert]], [[6i2h]], [[6i2d]], [[6i2b]], [[6eh3]], [[6egw]], [[5ous]], [[5ouc]], [[5oua]], [[5otg]], [[5ot3]], [[5ol3]], [[5ok3]], [[5o5m]], [[5o0e]], [[5nw8]], [[5ntj]] - haPKA + peptide inhibitor + inhibitor<br /> |
| - | **[[6erw]], [[ | + | **[[6erw]], [[6i2c]], [[6i2a]], [[5m75]], [[5m71]], [[5m6y]], [[5m6v]], [[5m0l]], [[5m0c]], [[5m0b]] - haPKA + peptide inhibitor + drug<br /> |
| - | **[[6i2a]] - haPKA + RPK153 + | + | **[[6i2a]] - haPKA + RPK153 + drug <br /> |
| - | **[[6i2c]], [[6i2d]] - haPKA + RPK182 + | + | **[[6i2c]], [[6i2d]] - haPKA + RPK182 + drug <br /> |
| + | **[[7axt]], [[7axv]], [[7axw]], [[7baq]], [[7bb0]], [[7pid]], [[7pie]], [[7pif]], [[7pig]], [[7pih]], [[7pns]] - haPKA + PKI + ligand<br /> | ||
*PKA catalytic subunit ternary complex with nucleotide | *PKA catalytic subunit ternary complex with nucleotide | ||
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**[[1atp]] - mPKA + peptide inhibitor + Mn-ATP<br /> | **[[1atp]] - mPKA + peptide inhibitor + Mn-ATP<br /> | ||
**[[6e21]] - mPKA + peptide inhibitor + ADP<br /> | **[[6e21]] - mPKA + peptide inhibitor + ADP<br /> | ||
| + | **[[7e0z]], [[7e11]], [[7e12]] - mPKA + PLN peptide + PPNP<br /> | ||
**[[6em7]], [[6em6]] - haPKA + peptide inhibitor + inhibitor + ADP<br /> | **[[6em7]], [[6em6]] - haPKA + peptide inhibitor + inhibitor + ADP<br /> | ||
**[[6eh2]] - haPKA + peptide inhibitor + inhibitor + AMP<br /> | **[[6eh2]] - haPKA + peptide inhibitor + inhibitor + AMP<br /> | ||
**[[6esa]] - haPKA + peptide inhibitor + ribose + AMP<br /> | **[[6esa]] - haPKA + peptide inhibitor + ribose + AMP<br /> | ||
**[[6ema]] - haPKA + peptide inhibitor + inhibitor + ATP<br /> | **[[6ema]] - haPKA + peptide inhibitor + inhibitor + ATP<br /> | ||
| + | **[[6y8c]] – haPKA + PKI peptide + ATP<br /> | ||
| + | **[[6y05]] – haPKA + PKI peptide + Adenine<br /> | ||
| - | *PKA regulatory subunit | + | *'''PKA regulatory subunit''' |
**[[4f9k]] – hPKA I-β<br /> | **[[4f9k]] – hPKA I-β<br /> | ||
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**[[1r2a]] - mPKA II dimerization-anchoring domain – NMR<br /> | **[[1r2a]] - mPKA II dimerization-anchoring domain – NMR<br /> | ||
**[[1l6e]] - mPKA II-α dimerization-anchoring domain – NMR<br /> | **[[1l6e]] - mPKA II-α dimerization-anchoring domain – NMR<br /> | ||
| - | **[[3of1]] - yPKA <br /> | + | **[[3of1]], [[6xqk]] - yPKA <br /> |
*PKA regulatory subunit binary complex | *PKA regulatory subunit binary complex | ||
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**[[5t3n]] - PfPKA + cAMP derivative – ''Plasmodium falciparum''<br /> | **[[5t3n]] - PfPKA + cAMP derivative – ''Plasmodium falciparum''<br /> | ||
**[[5kbf]], [[5k8s]] - PfPKA + cAMP <br /> | **[[5kbf]], [[5k8s]] - PfPKA + cAMP <br /> | ||
| + | **[[6h4g]] - PKA (mutant) + cAMP – ''Trypanosoma brucei''<br /> | ||
| + | **[[6rsx]] - PKA + cAMP – ''Euglena gracilis''<br /> | ||
*PKA regulatory subunit ternary complex | *PKA regulatory subunit ternary complex | ||
**[[3tmh]] - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide + NHERF-3<br /> | **[[3tmh]] - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide + NHERF-3<br /> | ||
| + | **[[8em8]] - PfPKA + peptide + inhibitor <br /> | ||
*PKA catalytic and regulatory subunits | *PKA catalytic and regulatory subunits | ||
Current revision
3D structures of cAMP-dependent protein kinase
Updated on 16-February-2023
