2wa2
From Proteopedia
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<StructureSection load='2wa2' size='340' side='right'caption='[[2wa2]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2wa2' size='340' side='right'caption='[[2wa2]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wa2]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2wa2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Modoc_virus Modoc virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WA2 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa2 OCA], [https://pdbe.org/2wa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wa2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wa2 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8QL64_9FLAV Q8QL64_9FLAV] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Modv]] | ||
| - | [[Category: Jansson, A M]] | ||
| - | [[Category: Johansson, P]] | ||
| - | [[Category: Jones, T A]] | ||
| - | [[Category: 2'-o-methyltransferase]] | ||
| - | [[Category: Envelope protein]] | ||
| - | [[Category: Flavivirus]] | ||
| - | [[Category: Membrane]] | ||
| - | [[Category: Methyltransferase]] | ||
[[Category: Modoc virus]] | [[Category: Modoc virus]] | ||
| - | [[Category: | + | [[Category: Jansson AM]] |
| - | [[Category: | + | [[Category: Johansson P]] |
| - | [[Category: | + | [[Category: Jones TA]] |
| - | + | ||
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Current revision
Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV)
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