Cell death protein

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Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code 3bik)

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References

↑ Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187 doi:http://dx.doi.org/10.1016/j.str.2015.09.010
↑ Xue D, Shaham S, Horvitz HR. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev. 1996 May 1;10(9):1073-83. PMID:8654923 doi:10.1101/gad.10.9.1073
↑ Wang Q, Yang HS. The role of Pdcd4 in tumour suppression and protein translation. Biol Cell. 2018 May 28:10.1111/boc.201800014. PMID:29806708 doi:10.1111/boc.201800014
↑ Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3011-6. Epub 2008 Feb 14. PMID:18287011
↑ Malottki K, Popat S, Deeks JJ, Riley RD, Nicholson AG, Billingham L. Problems of variable biomarker evaluation in stratified medicine research--A case study of ERCC1 in non-small-cell lung cancer. Lung Cancer. 2016 Feb;92:1-7. PMID:26775588 doi:10.1016/j.lungcan.2015.11.017
↑ Rho SB, Song YJ, Lim MC, Lee SH, Kim BR, Park SY. Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2. Cell Signal. 2012 Jan;24(1):131-9. PMID:21893193 doi:10.1016/j.cellsig.2011.08.013
↑ Xue D, Horvitz HR. Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor. Nature. 1997 Nov 20;390(6657):305-8. PMID:9384385 doi:10.1038/36889
↑ Lauenborg B, Kopp K, Krejsgaard T, Eriksen KW, Geisler C, Dabelsteen S, Gniadecki R, Zhang Q, Wasik MA, Woetmann A, Odum N. Programmed cell death-10 enhances proliferation and protects malignant T cells from apoptosis. APMIS. 2010 Oct;118(10):719-28. PMID:20854465 doi:10.1111/j.1600-0463.2010.02669.x

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Michal Harel, Alexander Berchansky

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 <StructureSection load='3bik' size='350' side='right' scene='50/507728/Cv/1' caption='Human CED-1 extracellular domain.  Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code [[3bik]])'>
-'''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis.  '''CED-1''' is a T cell regulator.  CED-1 is expressed on the surface of T cells, B cells and macrophages.  It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis.  CED-1 has 2 ligands: CED-L1 and CED-L2.  Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref>. For details on '''CED-8''' see [[Apoptosis-inducing factor]].
+'''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis.
+*'''CED-1''' is a T cell regulator.  CED-1 is expressed on the surface of T cells, B cells and macrophages.  It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis.  CED-1 has 2 ligands: CED-L1 and CED-L2.  Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> CED-1 and CED-L1 complex with glycerol</scene> ([[3bik]]).
+*'''CED-3''' is a cysteine protease involved in apoptosis<ref>PMID:8654923</ref>.
+*'''CED-4''' attenuates tumorigenesis by translational contro<ref>PMID:29806708</ref>.  lFor details on '''CED-4''' see [[CED-4 Apoptosome]]<ref>PMID:18287011</ref>. <br />
+*'''CED-5''' can accelerate apoptosis in different kinds of cells in response to different stimuli<ref>PMID:26775588</ref>.<br />
+*'''CED-6''' has a role in modulating cellular angiogenesis<ref>PMID:21893193</ref>.<br />
+*For details on '''CED-8''' see [[Apoptosis-inducing factor]].
+*'''CED-9''' prevents cells from undergoing programmed cell death,  It is similar to Bcl2<ref>PMID:9384385</ref>.<br />
+*'''CED-10''' regulates apoptosis in malignant T cells<ref>PMID:20854465</ref>.<br />
+[[Cell death protein 3D structures]]
 </StructureSection>
-==3D structures of cell death protein==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*CED-1
-**[[3rrq]] - hCED-1 extracellular domain (mutant) - human<br />
-**[[2m2d]] - hCED-1 extracellular domain - NMR<br />
-**[[4zqk]], [[5ius]] - hCED-1 extracellular domain (mutant) + hCED-1 ligand<br />
-**[[5wt9]], [[5jxe]], [[5b8c]] - hCED-1 extracellular domain + antibody<br />
-**[[5ggs]], [[5ggr]] - hCED-1 extracellular domain (mutant) + antibody<br />
-**[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br />
-**[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br />
-**[[3sbw]] - mCED-1 extracellular domain + hCED-L1 extracellular domain<br />
-**[[3rnq]] - mCED-1 extracellular domain + mCED-L2 extracellular domain<br />
-**[[3bp5]], [[3bp6]] - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain<br />
-**[[3rnk]] - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain<br />
-*CED-2
-**[[3qwx]], [[3qwy]] - CeCED-2 – ''Caenorhabditis elegans''
-*CED-3
-**[[4m9r]] - nCED-3 - nematode<br />
-*CED-4
-**[[2ggf]] – hCED-4 MA3 domain – NMR<BR />
-**[[2rg8]], [[2kzt]] - hCED-4 MA3 domain<BR />
-**[[3eij]] - hCED-4 residues 157-469<BR />
-**[[2zu6]], [[3eiq]] - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I<br />
-**[[2iol]], [[2ion]], [[2ios]], [[2nsz]] - mCED-4 MA3 domain<BR />
-**[[2hm8]] - mCED-4 MA3 domain – NMR<BR />
-**[[4m9s]], [[4m9x]], [[4m9y]], [[4m9z]] - nCED-4 + nCED-3 fragment<br />
-**[[2a5y]] - CeCED-4 + CeCED-9 <BR />
-**[[3lqq]], [[3lqr]] - CeCED-4<BR />
-*CED-5
-**[[1yyb]] - hCED-5 N terminal – NMR<BR />
-**[[2cru]], [[2k6b]] - hCED-5 – NMR<BR />
-*CED-6
-**[[2zn8]], [[2zn9]], [[2znd]], [[2zrs]], [[2zrt]] - hCED-6<br />
-**[[3aaj]], [[3aak]] - hCED-6 (mutant)<br />
-**[[2zne]] - hCED-6 + CED-6-interacting protein<br />
-**[[3wxa]] - hCED-6 + SEC31A peptide<br />
-**[[5gqq]] - hCED-6 + heme-binding protein<br />
-**[[1hqv]] - mCED-6<br />
-**[[1y1x]] - CED-6 – ''Leishmania major''<br />
-*CED-8 (apoptosis-inducing factor 1)
-**[[1m6i]], [[4bv6]], [[4lii]] - hCED-8<br />
-**[[5fmh]], [[5kvh]], [[5kvi]], [[5fs6]], [[5fs7]], [[5fs8]], [[4fdc]] – hCED-8 (mutant)  <br />
-**[[5fs9]] – hCED-8 (mutant)  + FAD<br />
-**[[4bur]] – hCED-8 + NAD <br />
-**[[1gv4]], [[3gd3]] - mCED-8<br />
-**[[3gd4]] – mCED-8 + NAD <br />
-**[[5miu]] – mCED-8 (mutant) + FAD <br />
-**[[5miv]] – mCED-8 (mutant) + FAD + NAD<br />
-*CED-9
-**[[1ohu]] – CeCED-9 <BR />
-**[[1ty4]] - CeCED-9 + programmed CED activator
-*CED-10
-**[[3ajm]] - hCED-10 + inositol tetrakisphosphate<br />
-**[[3l8i]], [[3l8j]] - hCED-10<br />
-**[[3rqe]], [[3rqf]], [[3rqg]] - hCED-10 + paxillidin peptide<br />
-**[[3w8h]], [[3w8i]], [[4geh]] - hCED-10 + serine/threonine kinase regulatory domain<br />
-*CED-HAC-1
-**[[4v4l]] – CED-HAC-1 – ''Drosophila melanogaster''
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]

Cell death protein

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