User:Eric Martz/Antibody Quiz
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==Antibody Quiz== | ==Antibody Quiz== | ||
| - | You will get immediate feedback when you click ''Submit'' (at the bottom of the quiz). The quiz below is offered to accompany the Antibody structure tutorial at [http://molviz.org MolviZ.Org]. | + | You will get immediate feedback when you click ''Submit'' (at the bottom of the quiz). The quiz below is offered to accompany the Antibody structure tutorial at [http://molviz.org MolviZ.Org]. |
| + | |||
| + | <!-- (i) = case Insensitive. _7 = width of slot (number of characters) for answer. --> | ||
<quiz display=simple> | <quiz display=simple> | ||
| + | |||
| + | {How many "arms" does one antibody molecule have? | ||
| + | |type="{}"} | ||
| + | { 3|three (i)|three. (i) _7 } | ||
| + | || | ||
| + | |||
{ | { | ||
|type="{}"} | |type="{}"} | ||
| - | + | How many '''Fab''' "arms" does one antibody molecule have? | |
| - | { | + | { 2|two (i)|two. (i) _7 } |
| - | || | + | || |
| + | { | ||
| + | |type="{}"} | ||
| + | How many '''Fc''' "arms" does one antibody molecule have? | ||
| + | { 1|one (i)|one. (i) _7 } | ||
| + | || | ||
| - | {'''Questions below may have <font color="red">more than one</font> correct answer.'''} | + | { |
| + | |type="{}"} | ||
| + | How many CDRs are in one paratope? | ||
| + | { 6|six (i)|six. (i) _7 } | ||
| + | ||Three in the light chain variable domain plus three in the heavy chain variable domain. | ||
| + | |||
| + | { | ||
| + | |type="{}"} | ||
| + | What is the term for the smallest part of IgG1 that binds to antigen? | ||
| + | { Fv (i)|Fv. (i) _7 } | ||
| + | ||The variable fragment, containing only the variable domains: Fv. | ||
| + | |||
| + | {<hr>'''An IgG1 molecule has a molecular weight of 150 kilo Daltons.'''} | ||
| + | |||
| + | { | ||
| + | |type="{}"} | ||
| + | What is the approximate molecular weight of one immunoglobulin domain in kD? | ||
| + | { 10-13 _7 } kD. | ||
| + | ||Twelve Ig domains in one IgG1 molecule. 150/12 = 12.5 kD. | ||
| + | |||
| + | { | ||
| + | |type="{}"} | ||
| + | What is the approximate molecular weight of a single Fc in kD? | ||
| + | { 48-55 _7 } kD. | ||
| + | ||Fc is one of three roughly equal-sized arms, each containing 8 Ig domains. 150/3 = 50 kD. | ||
| + | |||
| + | {<hr> | ||
| + | '''Questions below may have <font color="red">more than one</font> correct answer.'''} | ||
| - | { | + | {Antibody |
|type="[]"} | |type="[]"} | ||
| - | + | + | + Binds to antigen. |
| - | - | + | + When bound to a microbe, recruits macrophages and other leukocytes to kill the microbes. |
| - | + | + | + Defends us against infections. |
| - | - | + | - Carries oxygen to tissues. |
| - | + | + | - Is a hormone. |
| + | - Strengthens bones. | ||
| + | || | ||
| + | |||
| + | |||
| + | {Antibody molecules consist of | ||
| + | |type="[]"} | ||
| + | + Protein. | ||
| + | - Lipid. | ||
| + | - Salt. | ||
| + | + Sugars. | ||
| + | + Carbohydrate. | ||
| + | + Amino acids. | ||
| + | - Fatty acids. | ||
| + | + Immunoglobulin domains. | ||
| + | || | ||
| + | |||
| + | {Antibody is manufactured by | ||
| + | |type="[]"} | ||
| + | - T lymphocytes. | ||
| + | - The liver. | ||
| + | + B lymphocytes. | ||
| + | - Antigen. | ||
| + | - G lymphocytes. | ||
| + | - Macrophages. | ||
| + | || | ||
| + | |||
| + | {Variable immunoglobulin domains | ||
| + | |type="[]"} | ||
| + | + Are in Fab. | ||
| + | - Are in Fc. | ||
| + | + Are in all antibodies. | ||
| + | - Have no disulfide bonds. | ||
| + | - Do not contain CDRs. | ||
| + | - Make up the epitope. | ||
| + | + Make up the paratope. | ||
| + | - Have the same amino acid sequence in all antibodies of a given subclass. | ||
| + | || | ||
| + | |||
| + | {A single immunoglobulin domain contains | ||
| + | |type="[]"} | ||
| + | - Three beta sheets. | ||
| + | + Two beta sheets. | ||
| + | - One beta sheet. | ||
| + | - Two alpha helices. | ||
| + | - One alpha helix. | ||
| + | + One disulfide bond. | ||
| + | - Two disulfide bonds. | ||
| + | - A hydrophilic core. | ||
| + | + A hydrophobic core. | ||
| + | || | ||
| + | |||
| + | {Which CDRs contribute the most to antigen specificity? | ||
| + | |type="[]"} | ||
| + | - Light chain CDRs. | ||
| + | - Heavy chain CDRs. | ||
| + | - CDR1s. | ||
| + | - CDR2s. | ||
| + | + CDR3s. | ||
| + | - CDR4s. | ||
|| | || | ||
</quiz> | </quiz> | ||
| - | Suggestions to | + | Suggestions to [[Special:Emailuser/Eric_Martz|Eric Martz]]. |
Educators are invited to copy this quiz into a Proteopedia page of your own, where you | Educators are invited to copy this quiz into a Proteopedia page of your own, where you | ||
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at the top, then block and copy everything in the box. Paste that into the wikitext box | at the top, then block and copy everything in the box. Paste that into the wikitext box | ||
of your own new page, and save the page. See [[Proteopedia:How to Make a Page]].) | of your own new page, and save the page. See [[Proteopedia:How to Make a Page]].) | ||
| - | |||
| - | ==Answers to Open-Ended Questions== | ||
| - | Here are answers to the questions provided in a document with the Antibody tutorial. | ||
| - | |||
| - | # <!--1-->Antibody bound to foreign microbes flags them for destruction. This is called "opsonization". Antibody triggers various white blood cells to kill microbes. Antibody bound to viruses can render them non-infectious. Binding of antibody to toxins can neutralize their toxicity. Mothers can give some of their antibodies (primarily IgA) to their babies through their breast milk. | ||
| - | # <!--2-->Antibody can cause auto-immune diseases, such as Lupus, rheumatoid arthritis, and Grave's disease. When too much antigen enters the body, antibody:antigen complexes can clog filtration in the kidneys, causing kidney damage called glomerulonephritis. | ||
| - | # <!--3-->People with a rare genetic birth defect called ''agammaglobulinemia'' are unable to make antibodies. They are susceptible to recurrent infections caused by bacteria that do not "hide" inside cells of the host's body: extracellular infections. These include Staphylococci, Streptococci, ''Hemophilus influenzae, Mycoplasma, Pseudomonas'', and ''Vibrio cholerae''. The best therapy is intravenous injection of purified antibodies pooled from healthy donors. | ||
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[[Category:Pages with quizzes]] | [[Category:Pages with quizzes]] | ||
Current revision
Antibody Quiz
You will get immediate feedback when you click Submit (at the bottom of the quiz). The quiz below is offered to accompany the Antibody structure tutorial at MolviZ.Org.
Suggestions to Eric Martz.
Educators are invited to copy this quiz into a Proteopedia page of your own, where you could delete some questions and add some of your own. (Click the tab edit this page at the top, then block and copy everything in the box. Paste that into the wikitext box of your own new page, and save the page. See Proteopedia:How to Make a Page.)
