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1c16

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[[Image:1c16.gif|left|200px]]
 
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==CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22==
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The line below this paragraph, containing "STRUCTURE_1c16", creates the "Structure Box" on the page.
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<StructureSection load='1c16' size='340' side='right'caption='[[1c16]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1c16]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C16 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c16 OCA], [https://pdbe.org/1c16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c16 RCSB], [https://www.ebi.ac.uk/pdbsum/1c16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c16 ProSAT]</span></td></tr>
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{{STRUCTURE_1c16| PDB=1c16 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q31615_MOUSE Q31615_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c16_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c16 ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22'''
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==See Also==
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class Ib proteins that bind to certain gammadelta T cell receptors (TCRs) in the absence of other components. The crystal structure of T22b at 3.1 angstroms reveals similarities to MHC class I molecules, but one side of the normal peptide-binding groove is severely truncated, which allows direct access to the beta-sheet floor. Potential gammadelta TCR-binding sites can be inferred from functional mapping of T10 and T22 point mutants and allelic variants. Thus, T22 represents an unusual variant of the MHC-like fold and indicates that gammadelta and alphabeta TCRs interact differently with their respective MHC ligands.
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==About this Structure==
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1C16 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C16 OCA].
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==Reference==
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Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold., Wingren C, Crowley MP, Degano M, Chien Y, Wilson IA, Science. 2000 Jan 14;287(5451):310-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10634787 10634787]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Chien Y]]
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[[Category: Chien, Y.]]
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[[Category: Crowley MP]]
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[[Category: Crowley, M P.]]
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[[Category: Degano M]]
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[[Category: Degano, M.]]
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[[Category: Wilson IA]]
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[[Category: Wilson, I A.]]
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[[Category: Wingren C]]
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[[Category: Wingren, C.]]
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[[Category: Beta2-microglobulin]]
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[[Category: Major histocompatibility]]
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[[Category: Non-classical mhc-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:12:32 2008''
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Current revision

CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22

PDB ID 1c16

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