6ziw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The IRAK3 Pseudokinase Domain Bound To ATPgammaS== |
| + | <StructureSection load='6ziw' size='340' side='right'caption='[[6ziw]], [[Resolution|resolution]] 2.18Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ziw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZIW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ziw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ziw OCA], [https://pdbe.org/6ziw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ziw RCSB], [https://www.ebi.ac.uk/pdbsum/6ziw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ziw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN] Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2]<ref>PMID:10383454</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Interleukin-1 receptor-associated kinase|Interleukin-1 receptor-associated kinase]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Chatterjee | + | </StructureSection> |
| - | [[Category: Knapp | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chatterjee D]] |
| + | [[Category: Knapp S]] | ||
| + | [[Category: Kraemer A]] | ||
| + | [[Category: Mathea S]] | ||
| + | [[Category: Preuss F]] | ||
Current revision
The IRAK3 Pseudokinase Domain Bound To ATPgammaS
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