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6zk0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6zk0 is ON HOLD Authors: Bax, B.D., Fenn, G.D. Description: 1.47A human IMPase with ebselen Category: Unreleased Structures [[Category: Bax, B....) |
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| - | '''Unreleased structure''' | ||
| - | + | ==1.47A human IMPase with ebselen== | |
| + | <StructureSection load='6zk0' size='340' side='right'caption='[[6zk0]], [[Resolution|resolution]] 1.47Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6zk0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZK0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9JT:N-phenyl-2-selanylbenzamide'>9JT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zk0 OCA], [https://pdbe.org/6zk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zk0 RCSB], [https://www.ebi.ac.uk/pdbsum/6zk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zk0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IMPA1_HUMAN IMPA1_HUMAN] Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.<ref>PMID:17068342</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Bax | + | __TOC__ |
| - | [[Category: Fenn | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bax BD]] | ||
| + | [[Category: Fenn GD]] | ||
Current revision
1.47A human IMPase with ebselen
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