6pln
From Proteopedia
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==X-ray crystal structure of Pyrococcus furiosus general transcription factor TFE-alpha== | ==X-ray crystal structure of Pyrococcus furiosus general transcription factor TFE-alpha== | ||
| - | <StructureSection load='6pln' size='340' side='right'caption='[[6pln]]' scene=''> | + | <StructureSection load='6pln' size='340' side='right'caption='[[6pln]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLN OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6pln]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PLN FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pln OCA], [https://pdbe.org/6pln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pln RCSB], [https://www.ebi.ac.uk/pdbsum/6pln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pln ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TFE_PYRFU TFE_PYRFU] Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.<ref>PMID:17921145</ref> <ref>PMID:17965161</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Pyrococcus furiosus]] | ||
[[Category: Jun SH]] | [[Category: Jun SH]] | ||
[[Category: Murakami KS]] | [[Category: Murakami KS]] | ||
Current revision
X-ray crystal structure of Pyrococcus furiosus general transcription factor TFE-alpha
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