6m5m

<table><tr><td colspan='2'>[[6m5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saxidomus_purpuratus Saxidomus purpuratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M5M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6M5M FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6a7t|6a7t]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6m5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m5m OCA], [http://pdbe.org/6m5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m5m RCSB], [http://www.ebi.ac.uk/pdbsum/6m5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m5m ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The C-type lectins SPL-1 and SPL-2 from the bivalve Saxidomus purpuratus are composed of A and B chains and of two B chains, respectively. They bind specific carbohydrates containing acetamido groups, such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc), in a Ca(2+)-independent manner. Unlike ordinary C-type lectins, which require Ca(2+) ions for carbohydrate recognition, these lectins recognize specific carbohydrates mainly through interactions with the acetamido group without Ca(2+) ions, even though Ca(2+) enhances the binding affinity of these lectins, especially SPL-1. In the present study, the crystal structure of the SPL-1-GlcNAc complex in the presence of Ca(2+) revealed that the binding of SPL-1 to GlcNAc is stabilized by hydrogen bonds to the water molecule(s) coordinating Ca(2+), whereas in ordinary C-type lectins Ca(2+) directly forms coordinate bonds to the hydroxy groups of carbohydrates. These differences may also allow SPL-1 and SPL-2 to recognize both GlcNAc and GalNAc, which have different orientations of the 4-hydroxy group.

Novel carbohydrate-recognition mode of the invertebrate C-type lectin SPL-1 from Saxidomus purpuratus revealed by the GlcNAc-complex crystal in the presence of Ca(2).,Unno H, Higuchi S, Goda S, Hatakeyama T Acta Crystallogr F Struct Biol Commun. 2020 Jun 1;76(Pt 6):271-277. doi:, 10.1107/S2053230X20007256. Epub 2020 Jun 5. PMID:32510468<ref>PMID:32510468</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Hatakeyama, T]]

[[Category: Unno, H]]

[[Category: Sugar binding protein]]