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2xgv

From Proteopedia

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Structure of the N-terminal domain of capsid protein from Rabbit Endogenous Lentivirus (RELIK)

Structural highlights

2xgv is a 1 chain structure with sequence from Microcebus murinus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Lentiviruses are widespread in a variety of vertebrates, often associated with chronic disease states. However, until the recent discovery of the prehistoric endogenous lentiviruses in rabbits (RELIK) and lemurs (PSIV), it was thought that lentiviruses had no capacity for germline integration and were only spread horizontally in an exogenous fashion. The existence of RELIK and PSIV refuted these ideas, revealing lentiviruses to be present in a range of mammals, capable of germline integration, and far more ancient than previously thought. Using Gag sequences reconstructed from the remnants of these prehistoric lentiviruses, we have produced chimeric lentiviruses capable of infecting nondividing cells and determined structures of capsid domains from PSIV and RELIK. We show that the structures from these diverse viruses are highly similar, containing features found in modern-day lentiviruses, including a functional cyclophilin-binding loop. Together, these data provide evidence for an ancient capsid-cyclophilin interaction preserved throughout lentiviral evolution.

Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface.,Goldstone DC, Yap MW, Robertson LE, Haire LF, Taylor WR, Katzourakis A, Stoye JP, Taylor IA Cell Host Microbe. 2010 Sep 16;8(3):248-59. PMID:20833376^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Goldstone DC, Yap MW, Robertson LE, Haire LF, Taylor WR, Katzourakis A, Stoye JP, Taylor IA. Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface. Cell Host Microbe. 2010 Sep 16;8(3):248-59. PMID:20833376 doi:10.1016/j.chom.2010.08.006

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xgv"

@@ Line 3: / Line 3: @@
 <StructureSection load='2xgv' size='340' side='right'caption='[[2xgv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xgv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gray_mouse_lemur Gray mouse lemur]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XGV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XGV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xgv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Microcebus_murinus Microcebus murinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XGV FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xgu|2xgu]], [[2xgy|2xgy]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xgv OCA], [http://pdbe.org/2xgv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xgv RCSB], [http://www.ebi.ac.uk/pdbsum/2xgv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xgv ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xgv OCA], [https://pdbe.org/2xgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xgv RCSB], [https://www.ebi.ac.uk/pdbsum/2xgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xgv ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 33: / Line 33: @@
 __TOC__
 </StructureSection>
-[[Category: Gray mouse lemur]]
 [[Category: Large Structures]]
-[[Category: Goldstone, D C]]
+[[Category: Microcebus murinus]]
-[[Category: Haire, L F]]
+[[Category: Goldstone DC]]
-[[Category: Robertson, L E]]
+[[Category: Haire LF]]
-[[Category: Stoye, J P]]
+[[Category: Robertson LE]]
-[[Category: Taylor, I A]]
+[[Category: Stoye JP]]
-[[Category: Retroviral capsid]]
+[[Category: Taylor IA]]
-[[Category: Viral protein]]

2xgv

From Proteopedia

Current revision

Structure of the N-terminal domain of capsid protein from Rabbit Endogenous Lentivirus (RELIK)

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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